Clinical Curation Scientist

Help us change lives

At Exact Sciences, we’re helping change how the world prevents, detects and guides treatment for cancer. We give patients and clinicians the clarity needed to make confident decisions when they matter most. Join our team to find a purpose-driven career, an inclusive culture, and robust benefits to support your life while you’re working to help others.

Position Overview

The Clinical Curation Scientist supports quality assurance for outgoing patient reports specifically related to the interpretation of evidence-based oncology biomarkers for therapeutic decision-making. This role also participates in related projects or initiatives.

Essential Duties

Include, but are not limited to, the following:

• Participate in the interpretation and analysis of identified variants from clinical samples.

• Support translation of novel biomarkers into clinical practice by surveying published literature as well as clinical trial data.

• Monitor clinical guidelines for validated target drug associations for personalized cancer care.

• Participate in the upkeep of biomarker archives and biomarker-specific evidence dossiers, as well as update the literature repository for continuous biomarker maintenance.

• Contribute to projects or initiatives in support of Exact Sciences’ precision medicine efforts.

• Interact with external agencies in a positive, professional manner.

• Strong verbal and written communication skills.

• Strong team orientation.

• Ability to explain concepts to diverse audiences.

• Ability to prioritize and manage multiple projects simultaneously.

• Ability to work independently on multiple tasks and perform careful, detail-oriented work within a team environment.

• Demonstrated understanding of cancer genomics, signal transduction pathways, cancer cell biology, targeted therapeutics, and whole genome, exome, and/or RNA-sequencing.

• Demonstrated ability to critically evaluate and interpret scientific literature.

• Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork.

• Support and comply with the company’s Quality Management System policies and procedures.

• Maintain regular and reliable attendance.

• Ability to act with an inclusion mindset and model these behaviors for the organization.

• Ability to work on a mobile device, tablet, or in front of a computer screen and/or perform typing for approximately 75% of a typical working day.

• Ability to work on a computer and phone simultaneously.

• Ability to use a telephone through a headset.

• Ability to travel on an occasional basis away from work location, may include overnight/weekend travel.

• Regular and reliable attendance.

Minimum Qualifications

• Bachelor's degree in Human Genetics, Molecular Genetics, Genomics, Cancer Biology, Molecular Biology or related field.

• 5+ years of experience with variant curation and drafting interpretation language based on ACMG/ClinGen guidelines including strong expertise on using public databases, tools, and resources, such as NCBI, EBI, UCSC, IGV.

• 2+ years leading project teams.

• Excellent verbal and written communication skills are necessary to communicate complex genetic information to colleagues. to colleagues.

• Visual acuity is required to view computer screens.

• Demonstrated ability to perform the Essential Duties of the position with or without accommodation.

• Authorization to work in the United States without sponsorship.

Preferred Qualifications

• Ph.D. in Molecular and Cellular Biology, Biochemistry, Cancer Biology, or related field.

• 3+ year(s) of experience with genomic medicine and translational cancer research.

• Proven record of scientific achievement (e.g., presentations, publications in peer-reviewed journals, etc.)

• 1+ year(s) of relevant experience to include interpretation and approval of patient reports in a CLIA certified laboratory.

• Experience in selection therapy (FDA approved drugs and clinical trials) based on NGS molecular profiling?

• Experience in somatic/germline variant interpretation.

• Familiar with AMP/ASCO/CAP/NCCN/ACMG clinical guidelines.

Salary Range:

Exact Sciences is proud to offer an employee experience that includes paid time off (including days for vacation, holidays, volunteering, and personal time), paid leave for parents and caregivers, a retirement savings plan, wellness support, and health benefits including medical, prescription drug, dental, and vision coverage. Learn more about our benefits.

Our success relies on the experiences and perspectives of a diverse team, and Exact Sciences fosters a culture where all employees can develop personally and professionally with a sense of respect and belonging. If you require an accommodation, please contact us here.

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We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to disability, protected veteran status, and any other status protected by applicable local, state, or federal law.

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