Head of Development Sciences

| San Francisco
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Who we are:

Calico is a research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan and health span, and to devise interventions that enable people to lead longer and healthier lives. Executing on this mission will require an unprecedented level of interdisciplinary effort and a long-term focus for which funding is already in place.

Position description:

Calico is seeking a Head of Development Sciences. The Head of Development Sciences will - oversee Calico’s functional capabilities to enable late-stage pre-clinical and early-stage clinical development. This includes oversight of Calico’s biomarker, non-clinical pharmacology, and pathology groups, in support of Calico’s growing drug development pipeline. The role reports to Calico’s Head of Drug Development.

Position responsibilities:

  • Work in close collaboration with research scientists to identify, develop, and implement a strategy for preclinical support of program-related objectives
  • Contribute to formulating development plans for drug candidates with other functions within Calico as well as with external partners/collaborators
  • Contribute to Calico’s drug development review committee (DDRC) and sit on Calico’s development leadership team
  • Manage, mentor, advise and foster the career development of a diverse group of development sciences team professionals
  • Interface closely with functional leaders at AbbVie, Calico’s partner in drug development
  • Accountable for generation of data to enable selection of development candidates, to support regulatory filings and to enable innovative clinical development plans for first-in-class drug candidates
  • Participates in analysis of study results and presents conclusions to relevant decision boards
  • Contribute to the clinical development plan through clinical proof-of-concept studies in partnership with other functional areas. This includes an assessment of medical need, proposal of clinical development pathways, and review of preclinical data for clinical implications, acquisition of clinical samples and other relevant activities

Position requirements:

  • Applicants must have a Ph.D., M.D. or M.D./Ph.D. with broad experience in preclinical drug development
  • Applicants must have specific training and extensive expertise in Pathology, Pharmacology and/or Biomarker Development
  • Applicants should have significant working knowledge of other dimensions of drug development science, including toxicology, medicinal chemistry, and pharmacokinetics/pharmacodynamics
  • Extensive experience in biopharmaceuticals and drug development and a minimum of 10-15 years of relevant experience is required.
  • Relevant experience in preclinical development of both small and large molecule products
  • The candidate must have a strong scientific track record as evident from publications, IND/CTA filings and/or patents
  • Strong interpersonal skills are required, and the successful candidate will work in a cross-functional team and will be expected to influence the direction of the late-stage research programs
  • Must be a team player with the ability to influence project direction in a cross-functional team environment
  • Experience managing and developing team members



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Location

1170 Veterans Blvd. , South San Francisco, CA 94080

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