Biostatistical Manager #4010

Posted 14 Days Ago
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Menlo Park, CA
Hybrid
159K-199K Annually
Senior level
Artificial Intelligence • Big Data • Healthtech • Machine Learning • Software • Biotech
GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured.
The Role
The Staff Scientist Biostatistics will lead biostatistical activities, develop study protocols and statistical analysis plans, support clinical and real-world evidence study reporting, and contribute to regulatory submissions and publications. This role requires collaboration with cross-functional teams and staying updated on statistical methodologies and industry developments.
Summary Generated by Built In

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.


We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.


GRAIL is headquartered in Menlo Park, California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.


For more information, please visit grail.com.


The Biostatistical Manager will operate as a strategic thought leader in the Biostatistics Department to provide strategic input to GRAIL product pre-launch and post-launch activities including RWE generation

Responsibilities:

  • Contribute to the preparation of study protocols, development of statistical analysis plans, implementation of innovative statistical methods, writing programs to execute analyses, and assisting with the interpretation and dissemination of findings
  • In collaboration with cross-functional teams, lead and support reporting of clinical studies and RWE studies for regulatory submissions, health technology assessments (HTAs), and publications
  • Assist a variety of Clinical Development and Medical Affairs activities in developing abstracts, publications, and managing ad-hoc requests
  • Lead and support future studies that involve claims databases (e.g., MarketScan, Pharmetrics, etc), EMR/EHR (e.g., Flatiron’s oncology EHR databases), and registries
  • Stay abreast of industry and academic developments in the Statistical Genomics and real-world evidence generation and apply to clinical study design and analysis
  • Present some of the state-of-the-art statistical methodologies and issues via various departmental and company-wide meetings

Preferred Qualifications:

  • PhD in Biostatistics or related field with 5+ years (or MS with 8+ years) in academia or industry experience including at least 3 years of experience in the fields of RWE and Epidemiology.
  • Molecular diagnostics or pharmaceutical industry experience preferred
  • Familiarity with traditional performance metrics of clinical diagnostic tools
  • Strong knowledge of theoretical and applied statistics, particularly in the fields of epidemiology, health economics and outcomes research (HEOR), and RWE (e.g., propensity score matching/weighting, longitudinal data analysis, difference-in-differences estimation, synthetic/historical control arms, indirect treatment comparisons, network meta analysis, count data regressions, parametric/non-parametric survival analysis (e.g., competing risks models, multi-state models, frailty random effects models, etc)
  • Outstanding verbal, writing, and presentation skills with a strong ability to influence and communicate effectively throughout all levels of the organization and externally
  • Demonstrated success leading the statistical portion of post-launch product evaluation in the diagnostic/IVD or pharmaceutical industry is a plus
  • Knowledge of applicable regulatory rules and guidelines, not limited to ICH, GCP, HIPAA, NICE, and other RWE guidelines
  • Experience programming in R or related programming environment (e.g. SAS)

The expected, full-time, annual base pay scale for this position is $159K - $199K. Actual base pay will consider skills, experience, and location.


Based on the role, colleagues may be eligible to participate in an annual bonus plan tied to company and individual performance, or an incentive plan. We also offer a long-term incentive plan to align company and colleague success over time.


In addition, GRAIL offers a progressive benefit package, including flexible time-off, a 401k with a company match, and alongside our medical, dental, vision plans, carefully selected mindfulness offerings.


GRAIL is an Equal Employment Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. GRAIL maintains a drug-free workplace.

Top Skills

Biostatistics

What the Team is Saying

Neda Ronaghi
Ruth Mauntz
Allie Ahn
Maryam Hosseini
David Jenions
Satnam Alag
The Company
Menlo Park, CA
1,300 Employees
Hybrid Workplace
Year Founded: 2016

What We Do

GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is using the power of high-intensity sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop and commercialize pioneering products

Why Work With Us

Everything we do is guided by our mission to detect cancer early, when it can be cured. It’s the reason we’re here, and it’s no small task.

The right people make all the difference. That’s why we’re looking for those who strive to share their knowledge, contribute their skills, inspire each other and commit to something bigger than themselves.

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GRAIL Offices

Hybrid Workspace

Employees engage in a combination of remote and on-site work.

GRAIL has a variety of work types depending on the roles. Some are onsite like a lab role, others are hybrid and still others are remote.

Typical time on-site: Flexible
Menlo Park, CA

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