Jobs at Cytokinetics

Conduct in vivo and in vitro cardiovascular research supporting preclinical drug development. Responsibilities include rodent handling and dosing, tissue collection, primary cell isolation, ex vivo organ experiments, molecular and biochemical assays, iPSC-derived cardiomyocyte and engineered heart tissue studies, and assay development. The role requires independent experimental design, troubleshooting, data interpretation, project ownership, and collaboration across scientific disciplines.

Scientist I will design and synthesize novel small molecules for cardiovascular and neuromuscular drug discovery programs. Responsibilities include compound design, organic synthesis, chromatographic purification, compound characterization, multi-parameter optimization, computational modeling with tools such as MOE, and interpretation of biology and DMPK data. The role contributes to cross-functional project teams, documents experiments in an electronic lab notebook, and communicates research progress and findings.

Lead statistical support for clinical development, including protocol design, statistical analysis plans, clinical trial analyses, regulatory submissions, and interpretation of complex biomedical data. Collaborate cross-functionally to guide clinical strategy, decision-making, and regulatory interactions. Apply advanced statistical, machine learning, and AI methods to clinical and observational datasets while contributing to innovation and best practices.

Lead HCP personal promotion marketing strategy and execution for cardiovascular therapies. Develop segmentation, positioning, messaging, promotional programs, and customer engagement initiatives while supporting launch readiness and brand growth. Partner with sales, medical affairs, market access, regulatory, legal, analytics, and omnichannel teams. Use market insights, competitive intelligence, and performance analytics to optimize commercial strategy, ensure compliance, and influence cross-functional execution.

Supports the CEO as a trusted administrative and strategic partner by managing complex calendars, executive and Board meetings, global travel, expenses, communications, confidential documents, stakeholder relationships, and special projects. The role requires exceptional discretion, autonomy, judgment, organization, business acumen, and responsiveness while coordinating with senior leaders, Board members, investors, partners, and other external stakeholders.

Serves as the strategic finance partner to Commercial functions, leading budgets, forecasts, long-range planning, operating expense and headcount management. Performs variance analysis, financial modeling, investment trade-off evaluation, launch and growth decision support, executive reporting, and board-level analysis. Builds scalable planning infrastructure, dashboards, and repeatable forecasting processes while advising senior leaders on financial risks, opportunities, and resource allocation.

Lead statistical genetics analyses (GWAS, fine-mapping, Mendelian randomization) and multi-omics integration to identify and prioritize genetic targets for cardiovascular and muscle diseases. Develop bioinformatics pipelines, manage large-scale genomic and clinical datasets, design AI/ML phenotyping methods, collaborate with biologists and clinicians, and communicate findings in publications and regulatory documents.

Lead statistician providing statistical leadership for clinical development and study design, SAPs, DMC coordination, regulatory submissions, exploratory analyses integrating multimodal data, mentoring staff, and advancing AI/ML-enabled insights across clinical programs.

Provide high-level, confidential administrative and operational support to the CFO and CFO organization, managing complex calendars, Board and audit materials, travel, meetings, executive communications, and special projects while handling sensitive financial and corporate information with discretion.

Leads enterprise strategy, business development analytics, drug revenue forecasting, valuation modeling, strategic planning, executive and board analyses, and the company’s AI initiative. Builds commercial forecasts from epidemiology, pricing, diagnosis, treatment, and uptake assumptions; develops rNPV, DCF, scenario, sensitivity, and transaction models; supports portfolio decisions and deal evaluations; coordinates AI governance and adoption; and delivers decision-ready recommendations to senior leadership and the Board.

Conduct preformulation assessments and develop formulations for poorly water-soluble small molecules supporting preclinical PK, pharmacology, and toxicology studies. Lead solid-form screening, solubility and stability testing, dissolution studies, and HPLC/UPLC method development. Manage laboratory timelines and contract research organizations, support candidate selection and first-in-human documentation, and author technical reports for CMC and regulatory use. Collaborate with cross-functional discovery, CMC, biology, chemistry, and pharmacokinetics teams.

Lead pricing governance, contracting, and market access analytics for GVAD. Develop deal modeling, performance dashboards, channel and distribution analyses, and actionable insights to inform contracting, revenue/rebate forecasts, and cross-functional decision-making.

Lead QA oversight for drug substance and drug product manufacturing and testing performed by CMOs/CTLs. Manage a QA team, approve batch records and GMP documents, oversee investigations/CAPAs, support inspections and audits, drive technology transfers, process validation, supplier oversight, and continuous improvement to ensure global regulatory compliance and product quality.

The Director of Operational Excellence will lead process improvement initiatives and enhance operational efficiency in Supply Chain and Manufacturing, ensuring high-quality medicine delivery. This role requires collaboration with stakeholders and expertise in Lean methodologies.

The Senior Director, CMC Lead will oversee product development strategy, leading CMC programs, and ensuring effective communication and governance across teams to support drug development and regulatory approval.

Lead enterprise Business Process Management for Global Supply Chain & Technical Operations: design end-to-end process architecture, govern process lifecycle, drive process performance and continuous improvement, enable inspection readiness and scalability, establish governance and KPIs, partner with Operational Excellence, IT, and functional leaders, and lead change adoption across Plan, Source, Make, Deliver, and Enable value streams.

Lead design and scale-up of small-molecule manufacturing routes, optimize reactions and processes, support tech transfer and CDMO collaboration, characterize materials using HPLC/LC-MS/NMR, maintain cGMP-compliant records, prepare technical reports and regulatory filings, and mentor junior scientists within cross-functional project teams.

The Associate Scientist will design and manage in vivo pharmacology studies, analyze biomarkers, and collaborate with various teams for preclinical development.