Jobs at Exelixis

Lead design and implementation of cloud security architectures, investigate and remediate security incidents, integrate security tooling into CI/CD pipelines, assess vulnerabilities, collaborate cross-functionally, and ensure regulatory compliance (SOX, FDA) while improving organizational security posture.

The Senior Corporate Counsel drafts and negotiates contracts, overseeing legal aspects of R&D transactions, while managing risks and guiding junior attorneys.

Leads the biostatistics function for clinical trials, providing statistical guidance and overseeing department standards while managing multiple projects and teams.

The Senior DMPK Director leads DMPK strategies for drug candidates, oversees studies, prepares regulatory documents, and collaborates across departments to inform drug development decisions.

The Associate Principal Architect will design and implement cloud-based data architectures on AWS and Databricks, manage data governance, and lead CI/CD pipelines, optimizing for security and performance in advanced analytics settings.

Lead a portfolio of digital products for pharmaceutical R&D, clinical, and commercial functions. Define strategy and roadmaps, lead agile product teams, manage vendors, ensure GxP/HIPAA/GDPR compliance, drive product delivery and operational stability, and track KPIs to optimize adoption and business value.

Leads in vivo pharmacology research for oncology drug discovery and development, designing and interpreting PK, PD, efficacy, and toxicity studies in rodent tumor models. Represents Pharmacology on project teams, coordinates CRO studies, prepares study reports and IND filing materials, supports animal facility operations, and ensures IACUC and animal welfare compliance. The role may supervise a small team and requires advanced expertise in tumor models, experimental design, data analysis, cell culture, animal procedures, and pharmacology laboratory software.

The Director oversees CMC development and manufacturing operations for pharmaceutical projects, ensuring effective execution, risk management, and collaboration with internal and external teams.

Lead strategy, architecture, delivery, and operations of enterprise AI platforms and AI-enabled solutions. Define roadmap, build reusable AI capabilities, deliver production-grade generative and agentic AI, establish AI-native engineering practices, ensure responsible AI governance, and partner with cross-functional stakeholders to scale AI adoption and measure business impact.

Build and test AI-enabled prototypes, internal tools, prompts, and agentic automations. Translate requirements into small software components, write basic unit tests, support prompt engineering and API integrations, document designs and runbooks, participate in code reviews and demos, and follow data privacy, security, and responsible AI practices while learning SDLC and team processes.

Serve as the primary FP&A business partner to Pharmaceutical Operations & Supply Chain (PSC). Build bottoms-up forecasts, own CMC financial planning, support monthly close and accruals, provide CAPEX and clinical trial forecasting support, drive financial discipline and training across PSC, and deliver strategic analyses and ad hoc projects to align operations with corporate targets.

Design and evolve a cloud analytics platform: define automation, IaC, CI/CD, and governance; lead complex projects; mentor engineers; ensure compliance and platform reliability for regulated biotech environments.

Lead and manage antibody-based biologics programs from discovery through IND, focusing on oncology, ADCs, and bispecifics. Oversee in vivo efficacy, PK/PD, and early toxicology studies; write nonclinical IND pharmacology sections; manage cross-functional and external collaborations; expand and mentor Pharm/Tox team; handle project planning, resource management, and communication with senior leadership.

Lead and manage biostatistics for early-phase oncology programs, providing statistical strategy, trial design and analysis, biomarker and translational medicine guidance, regulatory interaction, vendor/CRO oversight, team recruitment/development, and department standards/process improvements to ensure successful clinical development.

Build and prototype agent-based AI applications and workflows, connecting LLMs, prompts, tools, and APIs. Rapidly prototype then harden code, execute CI/CD and testing, write docs/runbooks, participate in reviews, and apply secure-by-design and responsible AI practices.

Design, build, and deploy production-grade agentic applications and multi-agent workflows that automate IT and business processes. Convert prototypes into hardened services, integrate LLMs and enterprise data sources, implement CI/CD and observability, author runbooks and docs, lead reviews and threat modeling, and apply secure-by-design and responsible AI practices.

Lead QA support for quality systems (Deviations, Change Control, CAPA) and Veeva enhancements; oversee clinical and commercial artwork and labeling reviews, vendor oversight, risk-based GxP strategy, metrics and continuous improvement, and inspection/audit readiness while partnering cross-functionally to resolve quality issues and drive timely, compliant record closure.

The Biostatistics Director leads statistical analysis and clinical trial design, collaborates with teams, manages CROs, and oversees statistical outputs for clinical trials, especially in oncology.

Lead development and execution of US promotional tactics for Cabozantinib in RCC, aligning messaging with brand objectives. Manage promotional budget, vendor/agency relationships, cross-functional collaboration (sales, medical, regulatory), and measure campaign performance while ensuring FDA and compliance adherence.

Lead biostatistics strategy, operations, tools, and personnel for clinical development. Oversee design and analysis of Phase I–IV studies, regulatory interactions, CRO/vendor management, SOPs, budgets, and cross-functional scientific leadership to ensure data integrity, quality, and timely deliverables supporting drug development.