GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured.

Process Engineer II, Assay Automation #3502

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Employer Provided Salary: 56,000-66,000 Annually
Salary data is provided by the employer. Please note this is not a guarantee of compensation.

GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL, LLC is a wholly-owned subsidiary of Illumina, Inc. (NASDAQ:ILMN). For more information, please visit

GRAIL is seeking a Process Engineer II to join the Global Development & Operations department in Menlo Park, CA to transfer a high throughput DNA processing assay for a Laboratory Developed Test. In this position, the candidate will work closely with Assay Development, Reagent Development, Operations, Equipment, and Software teams as we develop operational and maintenance procedures and processes for a groundbreaking, high-throughput laboratory. Candidates would ideally have hands-on experience in process development and documentation within a regulated environment.

This is an on-site role and requires you to be onsite 5 days a week in Menlo Park, CA 


  • Assist in building out our state-of-the-art sample processing platform and develop the necessary loading, usage, and maintenance procedures to support the system for continuous operation
  • Collaborate with Development teams in evaluating early-stage products and processes
  • Analyze data from various sources to update platform capacity models and simulate system throughput
  • Help the team balance operator efficiency, cost of goods, and maximize system uptime while upholding safety and compliance standards
  • Develop and maintain user manuals, process flow charts, Standard Operating Procedures (SOPs), and work instructions around your developed methods
  • Gather Critical Process Parameters (CCPs) and Critical Quality Attributes (CQAs) to support the development of equipment for GRAILs new companion and pharmaceutical diagnostics products
  • Work within multi-functional teams to transfer processes and equipment from Research and Development into Laboratory and Operations teams
  • Collaborate with other departments to define GRAILs assay specifications, drive equipment requirements, and develop test methods for asset qualification
  • Provide technical support during integration testing and contribute to troubleshooting efforts
  • Occasionally provide off-shift or weekend coverage to support technical team activities during development and validation phases

Preferred Qualifications:

  • BS (MS preferred) in an Engineering or Life Sciences Field
  • 3+ years of experience in manufacturing operational development, or support
  • Proven track record in writing and executing SOP’s, Work Instructions, and Test Protocols
  • Experience in creating and interpreting process and material flow diagrams
  • Familiarity with transferring prototypes and concepts from R&D into operational environments
  • Expertise in manufacturing or automation of clinical diagnostics, medical devices, or equivalent technologies
  • Strong background in liquid handling equipment such as Agilent, Hamilton, Beckman, Dynamic Devices, etc.
  • Knowledge of molecular biology to support equipment activities in a Next-Generation Sequencing (NGS) workflowHands-on experience in qualifying equipment within a high-throughput clinical laboratory setting
  • Applied knowledge of root cause analysis and troubleshooting techniques
  • Experience supporting commercial products and working cross-functionally across departments to capture system requirements and specifications 
  • Ability to take initiative and independently drive projects to completion with detailed and efficient execution and reporting
  • Willingness to travel up to 10% of the time to our facility in North Carolina

Physical Demands and Working Environment

  • Hours and days may vary depending on operational needs.
  • Standing or sitting for long periods of time may be necessary.
  • May be exposed to hazardous materials, blood specimens and instruments with moving parts, heating or freezing elements, and high speed centrifugation.

The estimated, full-time, annual base pay scale for this position is $90,000 - $107,000. Actual base pay will consider skills, experience, and location. 

Based on the role, colleagues may be eligible to participate in an annual bonus plan tied to company and individual performance, or an incentive plan. We also offer a long-term incentive plan to align company and colleague success over time.

In addition, GRAIL offers a progressive benefit package, including flexible time-off, a 401k with a company match, and alongside our medical, dental, vision plans, carefully selected mindfulness offerings.

GRAIL is an Equal Employment Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. GRAIL maintains a drug-free workplace.

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What are GRAIL Perks + Benefits

GRAIL Benefits Overview

We’re committed to creating the best experience for everyone at GRAIL, ensuring that each member of our team has comprehensive benefits and resources to thrive at all stages of life, both at work and at home.

Volunteer in local community
We parter with Bay Area local partners such as Life Science Cares to help meet basic needs in the community.
Partners with nonprofits
GRAIL partners with The Honor Foundation to facilitate mock interviews to help military professionals transition to civilian life. Also oSTEM and The National Sales Network to identify diverse talent.
Open door policy
OKR operational model
Team based strategic planning
Open office floor plan
Employee resource groups
Employee-led culture committees
Hybrid work model
In-person all-hands meetings
Employee awards
Flexible work schedule
Remote work program
Dedicated diversity and inclusion staff
Mandated unconscious bias training
Unconscious bias training is included as part of our standard interview training. We also have a formal training on the topic of unconscious bias that is facilitated by the People Team.
Diversity manifesto
Mean gender pay gap below 10%
Diversity employee resource groups
GRAIL proudly offers 4 employee resources groups led by team members in tandem with an executive sponsor. They include: ASERG, WERG, PRIDE, and BIPOCC.
Hiring practices that promote diversity
GRAIL's Talent team has partnered with a variety of non-profits, associations and job boards including WITI, oSTEM, THF, DiversityJobs and The National Sales Network to identify diverse talent.
Health Insurance + Wellness
Flexible Spending Account (FSA)
Disability insurance
Dental insurance
Vision insurance
Health insurance
Life insurance
Wellness programs
Team workouts
Mental health benefits
Abortion travel benefits
Financial & Retirement
401(K) matching
Company equity
Performance bonus
Pay transparency
Child Care & Parental Leave
Childcare benefits
Generous parental leave
Family medical leave
Company sponsored family events
Fertility benefits
Vacation + Time Off
Unlimited vacation policy
Paid holidays
Paid sick days
Flexible time off
Bereavement leave benefits
Company-wide vacation
Office Perks
Commuter benefits
Company-sponsored outings
Free daily meals
Free snacks and drinks
Some meals provided
Company-sponsored happy hours
Onsite office parking
Recreational clubs
Relocation assistance
Onsite gym
Professional Development
Job training & conferences
Promote from within
Mentorship program
Online course subscriptions available
Paid industry certifications

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