GRAIL

GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured.

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Senior Software Engineer, System Infrastructure #3433

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Employer Provided Salary: 155,000-175,000 Annually

GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL, LLC is a wholly-owned subsidiary of Illumina, Inc. (NASDAQ:ILMN). For more information, please visit www.grail.com.

GRAIL is seeking a Senior Software Engineer in our Systems Infrastructure team, where you'll play a pivotal role in developing large-scale computation platforms designed to handle petabytes of biological sequence data that is essential to our groundbreaking products in early cancer detection. This role is located in Menlo Park, Ca. with a hybrid work environment.

We develop tools and libraries aimed at rapidly iterating novel algorithms and analyses, focusing on large-scale efficiency, robustness, reproducibility, approachability, and composability. We focus on different aspects at different times, but these are all important to us:

> Large scale: Manage and process many petabytes of biological sequence data, engaging thousands of processors simultaneously.

> Efficiency: Test ideas rapidly and cost-effectively, enhancing our ability to explore numerous concepts.

> Robustness: Ensure users focus on scientific goals rather than computing cluster status.

> Reproducibility: Maintain deterministic and reproducible scientific analysis processes and results.

> Approachability: Make powerful distributed computing tools accessible to those unfamiliar with them.

> Composability: Enhance tool power by enabling their combined use.

Responsibilities

Design and develop robust, scalable, and efficient software systems for large-scale computation in cancer detection while adhering to security and compliance practices.
Utilize GRAIL tools and libraries we develop to iterate quickly on novel algorithms and analyses.
Work in a multi-disciplinary environment, ensuring software quality and operational excellence through rigorous testing and code reviews.
Contribute to open-source projects like Reflow, enhancing our distributed, incremental data processing capabilities.

Preferred Qualifications

Ideal candidate will have a BS/BA and 5+ years or a Masters and 2+ years of experience
Proficiency in building and supporting highly scalable systems on AWS.
Strong expertise in general-purpose programming languages such as Go, Python, Java, or JavaScript.
Experience with distributed computing concepts like cluster computing, caching, and fault tolerance.
Exceptional logical reasoning and analytical skills.
A detail-oriented approach in communication and engineering practices.
Experience designing simple, secure software solutions.
Strong written and verbal communication skills.
Additional skills highly preferred
Experience with GRPC
Experience with Infrastructure as Code (Terraform)
Experience with Gitlab CI/CD pipelines
Familiarity with next-generation sequencing, computational biology, or related fields.

The estimated, full-time, annual base pay scale for this position is $155,000 - $175,000. Actual base pay will consider skills, experience, and location.

Based on the role, colleagues may be eligible to participate in an annual bonus plan tied to company and individual performance, or an incentive plan. We also offer a long-term incentive plan to align company and colleague success over time.

In addition, GRAIL offers a progressive benefit package, including flexible time-off, a 401k with a company match, and alongside our medical, dental, vision plans, carefully selected mindfulness offerings.

GRAIL is an Equal Employment Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. GRAIL maintains a drug-free workplace.

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Joerg Bredno

Principal Scientist, Computational Biology and Interpretation

WIDEN YOUR SCOPE

A huge data set with an even bigger impact

“Cancer is a nasty, diverse disease that can affect widely different regions in the genome,” Principal Scientist Joerg Bredno said, and understanding how and why cells change isn’t easy. Luckily, his team works with more than 12 petabytes of molecular data — which translates to more than 1 million gigabytes — and a high-performance scientific computing environment that can handle analysis at that scale. With these tools, Bredno’s team is building an even larger training data set for the next generation of GRAIL’s early detection, multi-cancer screening test, slated to roll out this year.

It is rewarding that we can see, learn and share relevant insights from our data that so far doesn't exist anywhere else in the world in this form.

Ting Ma

Associate Director, Data Engineering

ACCELERATE TOGETHER

A team united by passion, fueled by collaboration

GRAIL’s team sets lofty goals for its products, which require the unique talents and perspectives of every employee. Take one eight-month study that Associate Director Ting Ma worked on, parsing data from a GRAIL-sponsored clinical trial. Due to the volume of data, teamwork was imperative to define and implement clinical features, refine codes with robust test cases and tweak them as continuous feedback rolled in. The work is important, but that's not the only plus: “Cross-functional team collaboration is fun,” Ma said. “You get to learn so much while contributing to each project.”

GRAIL is taking on a challenge that is unprecedented. It can only become successful when people with different expertise collaborate deeply.

Ying Luan

Associate Biostatistical Director

UNCOVER NEW OPPORTUNITIES

Sharp talent, perpetually looking to learn more

There’s a reason top talent, like Associate Biostatistical Director Ying Luan, joins GRAIL. “Here, I knew I could have the opportunity to contribute to the development of innovative analysis methodologies,” Luan said. She’s now working on a diagnostic aid project, planning and designing validation for clinical studies. It’s a new area for her, but there’s plenty of support for learning new skills at the company: With resources like LinkedIn Learning, workshops and conferences, she finds footing in the field, while diversity and inclusion trainings connect her fully to GRAIL’s culture.

Post-launch activities and payer’s reimbursement were new to me when I joined GRAIL. But now, I’m learning new things on a daily basis with different stakeholders in mind.

What are GRAIL Perks + Benefits

GRAIL Benefits Overview

We’re committed to creating the best experience for everyone at GRAIL, ensuring that each member of our team has comprehensive benefits and resources to thrive at all stages of life, both at work and at home.

Culture

Volunteer in local community

We parter with Bay Area local partners such as Life Science Cares to help meet basic needs in the community.

Partners with nonprofits

GRAIL partners with The Honor Foundation to facilitate mock interviews to help military professionals transition to civilian life. Also oSTEM and The National Sales Network to identify diverse talent.

Open door policy

OKR operational model

Team based strategic planning

Open office floor plan

Employee resource groups

Employee-led culture committees

Hybrid work model

In-person all-hands meetings

Employee awards

Flexible work schedule

Remote work program

Diversity

Dedicated diversity and inclusion staff

Mandated unconscious bias training

Unconscious bias training is included as part of our standard interview training. We also have a formal training on the topic of unconscious bias that is facilitated by the People Team.

Diversity manifesto

Mean gender pay gap below 10%

Diversity employee resource groups

GRAIL proudly offers 4 employee resources groups led by team members in tandem with an executive sponsor. They include: ASERG, WERG, PRIDE, and BIPOCC.

Hiring practices that promote diversity

GRAIL's Talent team has partnered with a variety of non-profits, associations and job boards including WITI, oSTEM, THF, DiversityJobs and The National Sales Network to identify diverse talent.

Health Insurance + Wellness

Flexible Spending Account (FSA)

Disability insurance

Dental insurance

Vision insurance

Health insurance

Life insurance

Wellness programs

Team workouts

Mental health benefits

Abortion travel benefits

Financial & Retirement