GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured.

Senior Software Engineer, System Infrastructure #3433

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Employer Provided Salary: 155,000-175,000 Annually
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GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL, LLC is a wholly-owned subsidiary of Illumina, Inc. (NASDAQ:ILMN). For more information, please visit

GRAIL is seeking a Senior Software Engineer in our Systems Infrastructure team, where you'll play a pivotal role in developing large-scale computation platforms designed to handle petabytes of biological sequence data that is essential to our groundbreaking products in early cancer detection. This role is located in Menlo Park, Ca. with a hybrid work environment. 

We develop tools and libraries aimed at rapidly iterating novel algorithms and analyses, focusing on large-scale efficiency, robustness, reproducibility, approachability, and composability. We focus on different aspects at different times, but these are all important to us:

> Large scale: Manage and process many petabytes of biological sequence data, engaging thousands of processors simultaneously.

> Efficiency: Test ideas rapidly and cost-effectively, enhancing our ability to explore numerous concepts.

> Robustness: Ensure users focus on scientific goals rather than computing cluster status.

> Reproducibility: Maintain deterministic and reproducible scientific analysis processes and results.

> Approachability: Make powerful distributed computing tools accessible to those unfamiliar with them.

> Composability: Enhance tool power by enabling their combined use.


  • Design and develop robust, scalable, and efficient software systems for large-scale computation in cancer detection while adhering to security and compliance practices.
  • Utilize GRAIL tools and libraries we develop to iterate quickly on novel algorithms and analyses. 
  • Work in a multi-disciplinary environment, ensuring software quality and operational excellence through rigorous testing and code reviews.
  • Contribute to open-source projects like Reflow, enhancing our distributed, incremental data processing capabilities.

Preferred Qualifications

  • Ideal candidate will have a BS/BA and 5+ years or a Masters and 2+ years of experience
  • Proficiency in building and supporting highly scalable systems on AWS.
  • Strong expertise in general-purpose programming languages such as Go, Python, Java, or JavaScript.
  • Experience with distributed computing concepts like cluster computing, caching, and fault tolerance.
  • Exceptional logical reasoning and analytical skills.
  • A detail-oriented approach in communication and engineering practices.
  • Experience designing simple, secure software solutions.
  • Strong written and verbal communication skills.
  • Additional skills highly preferred
  • Experience with GRPC
  • Experience with Infrastructure as Code (Terraform)
  • Experience with Gitlab CI/CD pipelines
  • Familiarity with next-generation sequencing, computational biology, or related fields.

The estimated, full-time, annual base pay scale for this position is $155,000 - $175,000. Actual base pay will consider skills, experience, and location. 

Based on the role, colleagues may be eligible to participate in an annual bonus plan tied to company and individual performance, or an incentive plan. We also offer a long-term incentive plan to align company and colleague success over time.

In addition, GRAIL offers a progressive benefit package, including flexible time-off, a 401k with a company match, and alongside our medical, dental, vision plans, carefully selected mindfulness offerings.

GRAIL is an Equal Employment Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. GRAIL maintains a drug-free workplace.

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What are GRAIL Perks + Benefits

GRAIL Benefits Overview

We’re committed to creating the best experience for everyone at GRAIL, ensuring that each member of our team has comprehensive benefits and resources to thrive at all stages of life, both at work and at home.

Volunteer in local community
We parter with Bay Area local partners such as Life Science Cares to help meet basic needs in the community.
Partners with nonprofits
GRAIL partners with The Honor Foundation to facilitate mock interviews to help military professionals transition to civilian life. Also oSTEM and The National Sales Network to identify diverse talent.
Open door policy
OKR operational model
Team based strategic planning
Open office floor plan
Employee resource groups
Employee-led culture committees
Hybrid work model
In-person all-hands meetings
Employee awards
Flexible work schedule
Remote work program
Dedicated diversity and inclusion staff
Mandated unconscious bias training
Unconscious bias training is included as part of our standard interview training. We also have a formal training on the topic of unconscious bias that is facilitated by the People Team.
Diversity manifesto
Mean gender pay gap below 10%
Diversity employee resource groups
GRAIL proudly offers 4 employee resources groups led by team members in tandem with an executive sponsor. They include: ASERG, WERG, PRIDE, and BIPOCC.
Hiring practices that promote diversity
GRAIL's Talent team has partnered with a variety of non-profits, associations and job boards including WITI, oSTEM, THF, DiversityJobs and The National Sales Network to identify diverse talent.
Health Insurance + Wellness
Flexible Spending Account (FSA)
Disability insurance
Dental insurance
Vision insurance
Health insurance
Life insurance
Wellness programs
Team workouts
Mental health benefits
Abortion travel benefits
Financial & Retirement
401(K) matching
Company equity
Performance bonus
Pay transparency
Child Care & Parental Leave
Childcare benefits
Generous parental leave
Family medical leave
Company sponsored family events
Fertility benefits
Vacation + Time Off
Unlimited vacation policy
Paid holidays
Paid sick days
Flexible time off
Bereavement leave benefits
Company-wide vacation
Office Perks
Commuter benefits
Company-sponsored outings
Free daily meals
Free snacks and drinks
Some meals provided
Company-sponsored happy hours
Onsite office parking
Recreational clubs
Relocation assistance
Onsite gym
Professional Development
Job training & conferences
Promote from within
Mentorship program
Online course subscriptions available
Paid industry certifications

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