Jobs at Natera

Receives, verifies, unloads, organizes, and stores deliveries in a warehouse environment. Compares purchase orders with invoices and packing lists, updates inventory, records transactions in Oracle, resolves discrepancies, and processes damaged or miss-shipped returns. Requires physical ability to lift up to 60 pounds and operate a pallet jack, along with basic math, communication, and warehouse systems experience.

Supports, troubleshoots, qualifies, maintains, and validates automated liquid-handling systems used in R&D and clinical diagnostics laboratories. Collaborates with scientists, engineers, end users, and cross-functional teams to prioritize support and improve laboratory workflows. Develops equipment documentation, user requirements, testing procedures, SOPs, and maintenance procedures; oversees IQ/OQ/PQ testing; provides user training; and contributes to automation system design, integration, and ongoing support.

Supervise the Signatera Plasma Team’s daily laboratory operations, including cfDNA extraction, library preparation, QC, and NGS workflows. Schedule staff, provide performance guidance, troubleshoot technical issues, and execute process development and instrument testing. Analyze deviations, document corrective actions, maintain SOPs and laboratory records, ensure regulatory sample management, and collaborate with oncology research teams to improve throughput. The role requires onsite work in San Carlos, California, with flexible and occasional weekend shifts.

Prepare and process tissue specimens and stained slides for whole exome/genome sequencing. Perform macrodissection, reagent and equipment prep, validations, reagent qualifications, case management, SOP updates, safety initiatives, supervise daily lab operations, train staff, troubleshoot equipment/processes, and document corrective actions.

Leads program management across pharmaceutical companion diagnostic partnerships from opportunity evaluation through execution and delivery. Assesses feasibility, scope, costs, timelines, resources, risks, and contractual alignment; advises Business Development and senior stakeholders; manages external pharmaceutical relationships; coordinates internal CDx teams; identifies portfolio-level risks; and establishes scalable governance frameworks and best practices.

Lead and grow the Data Science and Bioinformatics function for genomics clinical products. Build bioinformatics capability, architect scalable AWS infrastructure, implement MLOps and validation frameworks, establish quality and reproducibility standards for NGS algorithms, and hire/mentor a high-performing team while partnering cross-functionally to productize pipelines.

Individual contributor developing and implementing algorithms and pipelines to detect SNVs, indels, CNVs and SVs in low‑fraction cfDNA samples. Define caller strategies, prototype and benchmark methods, support complex production investigations, advise panel and assay design, and partner with quality, reporting, and lab groups to deploy clinically robust analysis methods.

Supervise day-to-day manufacturing and QC testing of consumable reagents in a regulated lab environment. Lead troubleshooting, workflow improvements, documentation and training, ensure regulatory compliance (GMP/GLP/CLIA/CAP/ISO13485), support audits and continuous improvement, and manage staffing, performance, and interdepartmental coordination.

The role involves owning the product roadmap for Oracle Fusion SCM, ensuring solution delivery, driving operational transformation, and compliance, while serving as a strategic partner to leaders in Supply Chain and Manufacturing.

The Program Manager will lead cross-functional programs in product development, ensuring compliance with regulatory requirements and stakeholder alignment, while driving execution of associated projects and managing risks.

Design, build, and productionize agentic LLM workflows to improve clinical data extraction quality and reliability. Integrate AI capabilities into production pipelines, ensure scalability and cost-effectiveness, develop evaluation/monitoring for safe deployment in regulated environments, and lead technical design and delivery with cross-team collaboration.

Designs and develops scalable customer-facing web applications and microservices APIs. Leads complex system architecture, performs code reviews, mentors engineers, defines technical implementations, and guides engineering vision. Maintains sustainable business systems, supports compliance initiatives, and improves development processes. The role requires Java and Spring experience, cloud technologies, relational databases, REST and event-driven architectures, containerization, front-end development, and software lifecycle expertise.

Manage federal, state, local, and international tax compliance, including income, sales and use, VAT, withholding, and property taxes. Oversee tax filings, reconciliations, projections, audits, controls, regulatory monitoring, third-party consultants, and tax planning. Drive process improvements, support internal and external audits, prepare journal entries, and communicate tax risks and opportunities to leadership. The role may require occasional evenings or weekends.

Lead product strategy and roadmap for digital experiences that support ongoing oncology testing and patient engagement. Simplify ordering, scheduling, and care-team workflows across physician portals, EHR systems, and patient portals. Partner with commercial, clinical, operations, engineering, and health-system integration teams. Own discovery through launch, define success metrics, analyze data, prioritize improvements, and communicate the roadmap to senior stakeholders.

Embed with a business domain to map workflows, design agent-enabled future-state processes, build and connect production automation (LLMs, agents, RAG), run and monitor agents with observability and evals, and partner with domain leaders to deliver measurable KPI improvements.

Work with a business domain to map workflows, design agent-driven workflows, build and integrate agent and automation pipelines, deploy and run agents in production, monitor KPIs and observability, and iterate with human-in-the-loop checkpoints to reliably improve business outcomes.

Lead technical pre-sales for EHR-integrated digital engagement solutions: support sales in discovery, RFPs, security assessments, pilots, and implementation. Liaise with product, engineering, EHR teams, contribute market-driven product strategy, and ensure successful customer onboarding and expansion.

Own and operate the Workday platform across HCM, Payroll, Recruiting, Prism, and Illuminate. Configure modules, build reports and integrations (EIB, Studio, APIs, RaaS), manage security models, tenant lifecycle, release readiness, analytics, automation, and compliance while partnering with HR, Payroll, Finance, and IT stakeholders.

Lead and grow Data Science and Bioinformatics for genomic clinical products. Build bioinformatics capability, architect scalable AWS infrastructure, implement MLOps and validation frameworks, enforce pipeline quality standards, collaborate cross-functionally, and hire and mentor a high-performing team to support Women's Health and Organ Health product roadmaps.

Lead strategy, development, and lifecycle management of an Early Cancer Detection product portfolio. Define vision and roadmap, conduct market and clinical research, build business cases, drive cross-functional launch and optimization, and grow a product management team to deliver regulated, algorithm-driven cfDNA diagnostics.