Jobs at Roche

Lead prototyping and scaling of AI-driven innovations (multi-agent systems, knowledge graphs, semantic integration) for clinical and real-world data. Design scalable data pipelines for unstructured and multi-modal data, run analytical innovation projects, build low/no-code platforms, ensure compliance (HIPAA/GDPR), collaborate across functions, mentor junior staff, and evaluate productization and governance of novel data solutions.

Lead hardware and software integration and characterization for a next-generation sequencing platform. Develop test methodologies, metrology tools, and modular software. Run experiments to analyze and optimize performance, troubleshoot high-speed data paths, and apply physics-based root cause analysis. Drive cross-functional projects and provide technical leadership to engineering teams.

Lead engineering for Diagnostics R&D, architecting AI/ML, laboratory informatics and data platforms. Own delivery, technical strategy, compliance, budgeting and stakeholder alignment while growing engineering teams and improving DevOps, MLOps and validation practices.

Hands-on role developing and optimizing novel NGS sequencing assays on the Axelios SBX platform. Lead experimental design, troubleshooting, and assay transfer to CLIA labs. Collaborate with commercial partners and bioinformatics to analyze data, document SOPs, mentor junior scientists, and drive strategic R&D initiatives to support pharma collaborations and diagnostic assay adoption.

Lead IHC functional screening and antibody development for rabbit monoclonals; develop, optimize, and validate IHC assays on FFPE samples; perform research testing and orthogonal confirmation (Western blot, ELISA, RNA ISH, IF); troubleshoot and improve antibody performance; provide scientific leadership and mentor junior staff; collaborate cross-functionally and contribute to publications, patents, and regulatory activities. Onsite in Pleasanton, CA.

Lead development and execution of risk-based Quality Assurance strategies across GCP/GVP/IVD/MD frameworks using the CtQ approach. Plan and perform global audits, synthesize findings into trend analyses, support regulatory inspection readiness, partner with international stakeholders, and drive PDQ process improvements using audit management and analytical reporting tools.

Design and develop automated verification tests for bioinformatics components and NGS pipelines. Work on scalable, distributed sequencing data analysis software, accelerate algorithms on GPUs, and support the software development lifecycle and Design Control process. Collaborate with research and algorithm experts to improve software quality and features for diagnostics.

Hands-on systems integration engineer for NGS products: design and run wet‑lab experiments, optimize single-molecule sequencing protocols, analyze data, troubleshoot instruments, and develop/execute verification and validation test cases while maintaining rigorous lab records.

Support Product Development Quality for the Molecular Lab - Sequencing Solutions portfolio. Ensure consistent interpretation of global requirements, integrate post-market feedback, drive design & development deliverables, enable risk-based decisions, support audits, resolve quality issues (CAPA/NC), and facilitate cross-functional project acceleration and milestone reviews.

Lead market expansion for sequencing products by mapping research ecosystems, engaging KOLs, defining product requirements, performing ROI and technological fit analyses, contributing to Design Control/PRD, and driving cross-functional teams to cultivate translational and basic research opportunities that grow long-term market adoption.

Design, develop, and test mechanical sub-systems (electro-mechanical, pneumatic, fluidic, thermal) for next-generation sequencing instruments. Own subsystem design, verification, integration, troubleshooting, CAD models and documentation, and collaborate cross-functionally to drive technical execution and resolve trade-offs.

Lead and deliver enterprise-wide GPS programs by establishing governance, roadmaps, and accountability. Drive cross-functional alignment, operational excellence, stakeholder engagement, risk management, and team leadership to ensure strategic initiatives are adopted and sustainably implemented.

The Principal Software Development Engineer will design, develop and automate testing frameworks for embedded instrument software, ensuring quality and compliance across development stages, while collaborating with global teams.

As a Senior Statistical Methodology Data Scientist, you will provide expert guidance on complex study designs and develop innovative statistical approaches to enhance evidence generation and decision-making across clinical development.

The Beyond TA Market Insights Leader at Roche leads market research and insights initiatives, shaping Pharma strategy through innovative methodologies, guiding commercial strategies, and developing best practices in insights delivery across therapeutic areas.

The Regulatory Affairs Manager at Roche oversees regulatory submissions, develops global strategies, and manages stakeholder relationships to ensure compliance and accelerate product approvals in diagnostics.

The role involves leading AI and digital solutions for market research, optimizing workflows, integrating technology solutions, and driving upskilling in insights product enablement within Roche's Pharma strategy.

The role leads global pharma portfolio insights, focusing on market analysis, strategic modeling, and collaboration across teams to enhance Roche's pharma strategy and identify opportunities and risks.

The Global Strategic Pricing Leader at Roche will develop and implement global pricing strategies, manage profitability, and support local teams with pricing governance and market access.

Lead development of molecular diagnostics reagents by synthesizing, purifying, and characterizing nucleotides, phosphoramidites, oligonucleotides and related small molecules. Develop and support analytical methods (chromatography, mass spectrometry, spectroscopy), troubleshoot processes, design experiments, transfer documentation to development/manufacturing, and act as a subject-matter expert across R&D and operations.