Top Chief of Staff Jobs in San Francisco, CA

Serve as a trusted executive partner to an AI R&D organization, driving strategy, stakeholder alignment, program delivery, financial and labor planning, organizational change, and associate engagement while enabling operational excellence.

Serve as a strategic partner and force multiplier to the Founder/CEO. Manage executive priorities, represent the CEO, drive ELT operating cadence and cross-functional alignment, prepare leadership and board materials, lead high-impact special projects, and implement AI tools to improve productivity. The role requires exceptional communication, analytical problem-solving, discretion, resilience, organization, and the ability to operate effectively in ambiguity.

Chief of Staff supporting Payer Partnerships and Clinical organizations. Translates executive strategy into cross-functional goals, drives initiative execution, tracks blockers, manages operating cadences, facilitates leadership decisions, writes decision memos and communications, and improves organizational processes. The role requires influencing without authority, managing multiple workstreams, bringing structure to ambiguity, and leading initiatives across Commercial, Clinical, R&D, Finance, Product, and other teams.

Serve as strategic partner to the Global Head of Sales by preparing executive and board materials, facilitating decisions, aligning cross-functional teams, leading sales planning and reporting, analyzing growth opportunities, and driving the sales organization’s operating rhythm. Lead global sales strategy initiatives, executive communications, meetings, offsites, and projects across GTM, Finance, People, Legal, and product teams.

Chief of Staff supporting the CEO by managing executive cadence, priorities, follow-through, and leadership communications. Builds AI-powered automations and workflows, runs company operating rhythms, supports executive onboarding, and owns cross-functional initiatives. Leads People Operations while supporting business and technology operations. The role requires hands-on execution, strong judgment, discretion, communication, and comfort working independently in a hybrid San Francisco environment.

Chief of Staff partnering with the CEO and founding team to drive company priorities, cross-functional initiatives, operating rhythms, fundraising support, metrics analysis, process improvement, hiring, and execution. The role operates across product, go-to-market, operations, and strategy in a remote, early-stage AI-native legal services company.

Chief of Staff responsible for operating and growing an AI community and conference business while supporting a day-zero venture fund. Owns operating plans, metrics, budgets, forecasts, P&L, sales, marketing, event production, finance, partner coordination, founder priorities, cross-functional projects, and execution across both organizations.

Serve as a force multiplier for the founders across go-to-market, operations, and strategy. Build and close sales pipeline through outbound, conferences, referrals, and partnerships; translate customer feedback into product decisions; prepare investor and partner conversations; and own internal administrative initiatives. The role requires startup operating experience, AI fluency, proven 0-to-1 go-to-market execution, strong communication, decisive problem-solving, and a high bias toward action.

Owns Eventual’s operating cadence, including planning, goals, metrics, board and investor materials, and company decisions. Leads customer and partner conversations, contracts, procurement, security reviews, go-to-market initiatives, pricing, hiring, and ambiguous cross-functional projects. This generalist role moves across operations, legal, sales, marketing, and strategy while building scalable systems and eventually developing functions into standalone teams.

Partner with the CEO to run company operations and cadence, embed with leadership, own cross-functional ambiguous problems, tighten planning/OKRs and reporting, represent the CEO in meetings, run board prep, hiring loops, and scale processes to drive measurable outcomes.

The Chief of Staff partners with the VP of Finance and Operations to run leadership meetings, prepare executive materials, track decisions, and drive follow-through. The role owns strategic and ad-hoc projects, manages cross-functional programs, develops business narratives, supports finance and operations leaders, conducts analysis, and makes recommendations. It requires strong financial modeling, communication, presentation, program management, and SaaS business knowledge.

Partner with the Chief Product Officer to drive high-priority organizational work. Responsibilities include tracking leadership commitments, investigating marketplace and operational problems through data analysis, reviewing planning documents, preparing status reports and executive briefings, and coordinating progress across Product, Engineering, Design, and other functions.

Work directly with the CEO and CTO to recruit exceptional talent, expand talent networks, close priority hires, and drive company-wide execution. Own critical initiatives, resolve operational bottlenecks, improve decision-making, establish hiring and execution reviews, and use AI tools to improve sourcing, reporting, and follow-through. The role requires hands-on recruiting, strong judgment, analytical communication, discretion, and the ability to deliver measurable results in a fast-growing AI and fintech company.

The Chief of Staff partners with Co-Executive Directors to advance programs, fundraising, organizational expansion, and mission execution. Responsibilities include leading OKRs and strategic planning, coordinating cross-team initiatives, representing executive leadership, evaluating programs, supporting administration and fundraising, managing stakeholder relationships, and preparing leadership for high-profile meetings and public appearances. This volunteer role requires 8–12 hours weekly, largely during U.S. work hours.

Serve as the CEO's strategic and operational right hand at an AI LegalTech startup: prepare executive/board/investor materials, build financial models and decks, contribute litigation expertise to product content, validate LLM-generated analyses, drive cross-functional execution, manage company operations (recruiting, vendor administration, OKRs), represent the CEO, and handle special projects across finance, legal, and partnerships.

Serve as the CEO’s strategic partner, owning company priorities, OKR planning, cross-functional special projects, board and investor communications, senior and clinical hiring, onboarding, and internal operating cadence. Lead ambiguous initiatives from analysis through launch, support fundraising and stakeholder engagement, and represent the company with partners and at industry events.

Works directly with the founder to translate company priorities into execution across hiring, operations, go-to-market, finance, and team systems. Brings structure to fast-moving workstreams, drives follow-through on critical decisions, and helps build scalable operating processes that support company growth and clarity.

Serve as the strategic and operational partner to the AI and Data Transformation & Analytics Practice Leader. Own leadership cadence, strategic initiative execution, AI governance, investment oversight, FP&A partnership, pipeline and revenue enablement, communications, and change management. Coordinate cross-functional stakeholders, improve practice operations, support executive forums, and ensure accountability, financial discipline, and alignment with firmwide strategy.

Serve as the CLO's Chief of Staff and lead Legal Operations: manage a small team and global legal budget, own legal vendor and tech strategy (CLM, e-billing, litigation tools), build dashboards and metrics, drive cross-functional integration, and implement AI-driven automation to improve reporting, decision-making, and operational efficiency across legal, corporate development, and IT.

Serves as the Chief Customer Officer’s strategic and operational partner, driving customer strategy execution, annual planning, cross-functional transformation initiatives, operating cadences, performance reporting, dashboards, and budget planning. Advises senior leaders, facilitates decision-making, coordinates executive meetings and reviews, analyzes business metrics, and leads organizational change across the customer organization.

Serves as Chief of Staff to the Chief Strategy Officer and leads Strategy Enablement. Owns annual strategic planning, ELT operating cadence, executive projects, initiative tracking, board content, and AI-enabled workflows. Partners with senior executives across the organization, represents the CSO, develops a small team, and translates strategic priorities into coordinated execution and executive-ready reporting.

Own and scale Valkai’s business operating systems across business operations, commercial strategy, revenue operations, recruiting, planning, and corporate functions. Build reusable playbooks, GTM data and tooling, forecasting processes, AI-native internal automations, hiring systems, company scorecards, and board materials. Partner closely with founders and the AI Strategy team to solve cross-functional problems and improve how the company operates as it grows.

Partner with the CEO to drive strategy and execution, remove organizational bottlenecks, translate decisions into cross-functional action, and represent the CEO externally. Build domain knowledge of AI/ML, GPU finance, and datacenter deal dynamics while coordinating leadership alignment and ensuring measurable outcomes. Role requires daily in-person presence in San Francisco.

Drive strategic execution for the AI Neobank: build operating rhythms, manage OKRs, coordinate cross-functional workstreams, prepare leadership/board materials, identify and mitigate risks, support trade-offs and special projects requiring senior judgment and cross-functional authority.

The Chief of Staff partners with the CEO and Leadership Team to run organizational operating rhythms, manage OKRs, coordinate executive preparation, advance strategic initiatives, and improve workflows. Responsibilities include integrating AI tools, managing CRM processes, overseeing events and retreats, supporting people operations, analyzing timesheets, and mentoring the Executive Operations Manager. The role requires strong strategic execution, communication, discretion, leadership, and comfort in fast-moving startup environments.