Top Chief of Staff Jobs in San Francisco, CA

Run operations for an AI community and conference business while supporting an early-stage venture fund. Own operating plans, metrics, budgets, forecasts, P&L, sales, marketing, event production, partnerships, and cross-functional execution. Translate founder priorities into action, prepare decisions, close follow-up loops, and drive ambiguous projects from concept through completion. The role is broad, in-person, and designed to develop into broader operating leadership.

Partner with the CEO to prioritize and execute strategic initiatives, prepare high-stakes meetings, manage follow-ups, support partner and customer opportunities, track the agentic payments market, coordinate executive events, and build AI-powered automations. The role requires independent judgment, strong writing and synthesis, technical fluency in payments and AI agents, and relentless cross-functional follow-through.

Serves as a trusted partner to the General Manager by communicating strategy, coordinating cross-functional priorities, maintaining organizational visibility, gathering employee feedback, supporting Shield integration, clarifying ownership, and driving follow-through. The role connects Aechelon employees, functional teams, and Shield while escalating issues requiring executive direction and preserving organizational culture and institutional knowledge.

Work directly with founders to drive strategic initiatives across hiring, customer delivery, go-to-market, and operations. Build operating systems, establish priorities and metrics, resolve cross-functional dependencies, automate repetitive work with AI tools, and take ownership of ambiguous problems from strategy through execution. The role requires strong analytical judgment, financial modeling, communication, discretion, and the ability to align technical and business teams in a fast-growing enterprise AI startup.

Work directly with the CEO to lead strategic and operational projects, improve AI-enabled workflows, coordinate legal and finance operations, support hiring and HR processes, and contribute to client development and go-to-market initiatives. The role requires strong analytical judgment, resourcefulness, communication, organization, discretion, and the ability to manage multiple priorities in a dynamic startup environment.

Chief of Staff responsible for building and leading internal operations, improving company systems and processes, representing leadership, driving cross-functional initiatives, managing a small operations team, strengthening employee experience, and improving internal communications. The role requires strong judgment, discretion, initiative, organizational ability, communication skills, and experience operating effectively in a demanding, growing organization.

Support the founding team by managing sales pipeline coordination, compliance calendars, audits, partner and investor communications, hiring logistics, suppliers, software administration, internal reporting, and company events. The role requires strong organization, writing, judgment, adaptability, and comfort handling broad administrative and operational responsibilities in a fast-moving fintech environment.

Support the CEO by managing his calendar, inbox, travel, meeting preparation, follow-ups, and priorities. Own action-item tracking, independently execute projects, operate AI agents and automations, and administer company tools and access. Support onboarding, offboarding, NDAs, vendor renewals, subscriptions, office needs, and events. The role requires discretion, sound judgment, strong organization, clear writing, adaptability, and comfort working in person within a fast-changing startup environment.

Chief of Staff serving as the CEO’s strategic and operational partner, driving execution, accountability, organizational maturity, government program delivery, compliance readiness, vendor management, financial forecasting, and strategic transactions. The role oversees directors and functional leads across operations, program management, marketing, and engineering support, with a strong focus on federal procurement, defense contracting, CMMC, DFARS, and NIST 800-171 requirements.

Partner with the CEO to lead strategic initiatives, foundational programs, operational improvements, executive communications, and AI-first transformation. Manage Events, Board, and Administrative teams; oversee the company technology stack; coordinate cross-functional delivery; improve processes, onboarding, documentation, and organizational effectiveness; and ensure CEO priorities are executed on schedule.

The Chief of Staff to the CEO drives executive operating rhythm, leadership team effectiveness, board and governance preparation, strategic planning, external engagement, enterprise priorities, and organization-wide change management. The role facilitates executive meetings, supports CEO decision-making, leads Executive Operations, coordinates special initiatives, tracks commitments, and ensures alignment across the National Leadership Team, board, and external stakeholders.

Work directly with the CEO to translate priorities into decisions, plans, ownership, and completed projects. Maintain operating cadences, improve hiring execution, coordinate suppliers and company workflows, drive customer and developer programs, support launches, write investor and internal communications, and build practical tracking systems. The role requires strong judgment, clear writing, ownership, adaptability, and hands-on follow-through across a fast-moving robotics company.

Supports the Chief of Staff by managing company priorities, follow-ups, escalations, operating rhythms, and cross-functional initiatives. Identifies process gaps, creates ownership and structure, drives commitments to completion, builds dashboards and playbooks, and handles urgent special projects such as launches, organizational changes, hiring pushes, and war rooms. The role requires hands-on execution, analytical problem-solving, and influencing teams without formal authority.

Serve as the CEO’s strategic and operational partner by preparing executive and board decisions, managing follow-through, and leading company planning rhythms. Own executive meetings, performance reviews, KPI frameworks, dashboards, internal communications, and annual planning. Lead cross-functional strategic initiatives, change management, and accountability across departments. Partner with Finance, Legal, and executive leaders on governance, investor updates, budgets, and company performance.

Partners with the CEO and Executive Leadership Team to translate strategy into execution, manage company planning and OKRs, prepare board and executive materials, analyze SaaS metrics, design leadership meetings, and drive cross-functional alignment and follow-through. Serves as a strategic advisor with broad influence, significant autonomy, and no people-management responsibilities.

Chief of Staff supporting the CEO with fundraising, donor and grant management, scholarship fund implementation, impact analysis, compliance infrastructure, board materials, organizational strategy, and strategic projects. The role requires building systems from scratch, coordinating internal and external partners, analyzing data, preparing communications, and facilitating leadership activities. It is remote within the United States with 20–30% travel and does not include executive assistant duties.

Chief of Staff supporting the CEO across company-wide execution and operating cadence. Responsibilities include owning special projects, improving clinical and member operations, supporting finance and reporting, designing people processes, coordinating goals and leadership meetings, preparing board and investor materials, and closing action items. The role requires strong analytical judgment, comfort with ambiguity, polished written work, cross-functional influence, and willingness to handle both strategic and hands-on operational tasks.

Leads product management standards, governance, operating models, portfolio planning, and organizational capabilities across a digital and eCommerce organization. Serves as Chief of Staff to digital leadership by translating strategy into priorities, operating rhythms, executive communications, decisions, and coordinated execution. Aligns Product, UX, Engineering, Data, Commercial, Finance, HR, and Operations teams while managing risks, dependencies, investments, talent planning, and strategic initiatives. Advances customer-centric, outcome-oriented, data-informed, and AI-enabled ways of working.

Lead Ambience’s Office of the President as an operating partner to the President and Co-Founder. Manage strategic workstreams, priorities, OKRs, partnerships, financial modeling, market analysis, deal structuring, board materials, and executive communications. Build and develop a team of operators, identify high-leverage issues, lead ambiguous initiatives, and establish AI-native operating systems for research, decision tracking, and knowledge management. The role requires working three days weekly from the San Francisco office.

Partner with the CEO to scale Lance by running the operating rhythm, leading special projects, building administrative and operational systems, managing legal and compliance processes, overseeing finance and vendors, and automating repetitive workflows with AI. The role also drives cross-functional initiatives across product, operations, and go-to-market while helping build and manage a growing team.

Work directly with the CEO on high-impact problems across operations, growth, finance, sourcing, and business intelligence. Own a department or product category, improve fulfillment and internal workflows, build AI-powered systems, develop supplier pipelines, support growth initiatives, create financial models and dashboards, and execute special projects. The role requires high agency, analytical strength, technical fluency, and comfort operating in a demanding onsite startup environment.

Support company founders by owning high-priority initiatives across fundraising, hiring, operations, and go-to-market. Run planning cycles, goals, metrics, meetings, and reviews; prepare presentations and validate internal data. Lead cross-functional projects spanning product operations, finance, partnerships, and recruiting while connecting product, engineering, and go-to-market teams. Identify problems early, develop recommendations, and build repeatable systems that ensure critical work reaches completion.

Serves as the CEO’s strategic partner, translating priorities into organizational alignment and decision-ready actions. The Chief of Staff filters issues for CEO attention, supports executive leadership coordination, prepares the CEO for Board and external engagements, represents delegated authority, and aligns Investment Committee work with Foundation strategy. The role influences without formal authority, drives cross-functional priorities, manages high-stakes information, and supports governance, fundraising, and major organizational decisions.

Coordinates executive calendars, travel, meetings, agendas, action items, and communications. Supports recruiting logistics, candidate communication, People team events, culture programming, and company offsites. Manages vendor coordination, expenses, process documentation, research, and other operational projects while identifying ways to improve company operations. The role requires discretion, urgency, independent prioritization, and collaboration across leadership, Growth, and People teams.

Supports strategic and cross-functional programs by coordinating timelines, deliverables, risks, dependencies, business reviews, and stakeholder activities. Tracks program performance, analyzes business data, identifies process improvements, and supports change management. The role also identifies opportunities to simplify and automate workflows using AI, agents, Copilot, low-code tools, APIs, and connectors, contributing hands-on to solution design, prototyping, testing, and implementation.