Top Chief of Staff Jobs in San Francisco, CA

Serve as a strategic surrogate to the Chief Strategy Officer: represent the CSO in meetings, craft executive communications and presentations, drive cross-functional strategy initiatives, monitor progress and alignment, collaborate with engineering/product/sales, and articulate the Strategy org's impact internally and externally. Requires technical fluency, strong analytics, and executive presence to accelerate high-impact projects and customer engagements.

Serve as a trusted executive partner to an AI R&D organization, driving strategy, stakeholder alignment, program delivery, financial and labor planning, organizational change, and associate engagement while enabling operational excellence.

Serve as strategic partner to the Enterprise GM to design and execute multi-year strategies and operating models. Lead cross-functional initiatives, align executive priorities and resource allocation, drive organizational change and operational excellence, synthesize insights for senior decision-making, and build relationships across VP+ leaders to mobilize company-level transformation.

The AI Chief of Staff will manage AI infrastructure, develop internal applications, evaluate vendors, and drive tool adoption across the company, enhancing efficiency and workflows.

Partner with the CEO to drive execution across planning, hiring, product, GTM, finance, and culture. Own operating cadence, track leadership priorities, lead cross-functional initiatives, prepare high‑stakes CEO communications, support board/investor and people processes, and build scalable systems to keep the company aligned and accountable.

Partner with the Chief People Officer to shape People strategy, run operating rhythms, prepare executive-ready materials, manage cross-functional initiatives, and lead high-priority confidential projects to drive alignment and execution across the People organization.

Own end-to-end outcomes for GTM, partnerships, and operations. Provide high-level strategic thinking with a bias for action, operate under ambiguous KPIs, and scale the function by hiring and extending teams as needed.

Partner with leadership to drive cross-functional execution, coordinate customers/hiring/operations, maintain follow-through on priorities, improve onboarding and processes, and act as an on-site general-purpose operator in a fast-paced startup.

The Chief of Staff/Business Operations Manager will drive strategic initiatives, optimize processes, and collaborate with executives to achieve company objectives.

The Chief of Staff will support the CEO by prioritizing company initiatives, driving cross-functional projects, and ensuring leadership alignment in a fast-paced environment.

The Chief of Staff will assist the CEO in strategic priorities, drive sales and product operations, manage investor relations, and oversee internal initiatives, ensuring organizational excellence and scaling efforts.

The Chief of Staff will partner with the CEO on strategic priorities and oversee cross-functional initiatives, ensuring alignment, accountability, and operational excellence throughout the organization.

Serve as strategic advisor and execution partner to the VP of IT Applications, leading cross-functional planning, governance, budget and roadmap alignment, translating strategy into operating cadence, executive communications, KPIs, and decision forums to drive organizational priorities and measurable outcomes.

Hands-on generalist operator who builds and owns legal, compliance (HIPAA), HR, payroll, accounting, vendor management, and day-to-day operations. Manages outside counsel, contract lifecycle, audits/certifications (e.g., SOC 2), onboarding/offboarding, payroll/AP/AR, and operational processes to scale a healthcare startup.

Partner with the CEO to convert strategy into execution: run high-priority cross-functional initiatives, prepare board materials, lead strategic analyses, manage operating cadence (meetings, all-hands, planning), resolve organizational bottlenecks, and align Product, Engineering, Finance, and GTM for rapid decision-making.

Work directly with the CEO to run company cadence, execute initiatives across hiring, growth, sales, marketing, partnerships and operations, handle admin (payroll, expenses, vendors), run customer interactions and demos, and build processes and automation to scale the business.

The Chief of Staff will design and execute strategic projects, support the CEO in go-to-market strategies, drive execution across teams, and manage operational systems.

Partner with the CEO to coordinate executive priorities, prepare communications and fundraising/board materials, evaluate partnerships, and use AI to automate G&A workflows while synthesizing company performance across functions.

Serve as strategic partner to the SVP of Product to scale product leadership: run leadership rhythms, own headcount and budget planning, drive AI enablement, curate external product narrative, manage org-health metrics, and resolve cross-functional structural issues to increase decision speed and org effectiveness.

Lead cross-functional initiatives for an early-stage fintech: drive GTM execution, own projects end-to-end, write PRDs and work with engineers/designers, run talent acquisition for hard-to-fill roles, prepare investor and board materials, visit customers and trade shows, and act as a hands-on strategic partner to the CEO.

The Chief of Staff will oversee strategic business moves, finance management, vendor negotiations, and develop partnerships, acting as a close advisor to the CEO.

The Chief of Staff will lead strategic initiatives for new business lines at Atticus, focusing on client acquisition and operational strategy while collaborating with various leaders.

Lead internal operations for a San Francisco ML startup: own vendor management, finance and SOC 2 compliance, automate billing and expense reviews, run office operations and onboarding, support HR/recruiting, and plan events and conference presence. Report to a co-founder and grow into hiring and culture interviews.

Work with founders and the founding team to build AI-powered internal tools and automations, run GTM and community activities, and manage daily operations. Own content, events, scheduling, vendor logistics, and process design while using AI tools to automate and ship solutions.

Partner with a co-founder to manage priorities, calendars, meetings, projects, and stakeholders. Drive execution, synthesize meeting outcomes, maintain systems (Forecast, SharePoint), troubleshoot basic tech issues, and improve processes to increase operational effectiveness in a fast-moving nonprofit consultancy.