Jobs at Nurix Therapeutics

Manage and improve Nurix’s electronic Quality Management System and core quality processes, including deviations, investigations, CAPAs, change controls, complaints, metrics, and data integrity. Lead eQMS implementation, configuration, validation, lifecycle management, reporting, and continuous improvement. Partner cross-functionally to support regulatory compliance, cGMP adherence, inspection readiness, training, and scalable quality-system operations across the growing biotechnology organization.

Leads nonclinical toxicology operations and program management for biopharmaceutical discovery programs from late lead optimization through IND filing. Responsibilities include planning GLP and non-GLP studies, managing CROs and contracts, tracking budgets and timelines, coordinating cross-functional teams, maintaining program dashboards and risk registers, supporting regulatory submissions, and driving milestone and decision-making processes across toxicology, DMPK, pharmacology, CMC, chemistry, and regulatory functions.

Leads analytical development and quality control activities for IND-enabling and early-phase clinical studies. Develops and validates methods, characterizes drug substances and products, manages stability programs, investigates deviations and out-of-specification results, and oversees analytical work at internal and external partners. Reviews technical documentation, establishes specifications and control strategies, supports regulatory filings, and ensures cGMP and SOP compliance. The role is onsite in Brisbane, California, with domestic and international travel.

Leads global regulatory strategy for hematology-oncology development programs, supporting clinical trials, marketing applications, health-authority interactions, submissions, compliance, and lifecycle management. Develops submission plans, tracks deliverables, assesses regulatory risks, maintains regulatory documents, supports systems and process improvements, and manages consultants. Collaborates cross-functionally to ensure compliance with FDA, EMA, ICH, and other global regulatory requirements.

Provides comprehensive administrative and operational support to senior research leaders, including calendar, travel, expense, meeting, event, conference, onboarding, and communications coordination. Partners cross-functionally with HR, Facilities, Legal, Finance, and Talent Acquisition; maintains departmental systems and records; supports governance meetings; and improves administrative processes. The role requires strong organization, judgment, discretion, communication skills, and the ability to manage shifting priorities in a fast-paced biotech environment.

Leads end-to-end chemical engineering support for small-molecule drug substance development and manufacturing through commercial launch. Responsibilities include process design, optimization, scale-up, equipment evaluation, technology transfer, CDMO oversight, GMP compliance, batch troubleshooting, regulatory filing support, lifecycle management, and cost optimization. The role partners with CMC, Quality, and Supply Chain teams, provides person-in-plant support, and mentors scientists and engineers.

Own FP&A and finance business-partner support for Research and G&A, including budgeting, forecasting, reporting, variance analysis, accrual close, revenue recognition, financial modeling, and long-range planning. Partner with cross-functional leaders on decision-making, resource allocation, process improvements, automation, and AI tooling. The role requires strong analytical, communication, organizational, and problem-solving skills in a fast-paced biotech environment.

Leads global clinical development programs from Phase 1 through approval and launch. Provides medical oversight for clinical trials, protocol design, safety and clinical data review, regulatory interactions, CRO and operational oversight, and cross-functional program leadership. Partners with executive, scientific, regulatory, commercial, and technical teams to develop strategy, manage risks, support IND/NDA/MAA activities, and communicate program results to internal and external stakeholders.

The Associate Director will manage the Computer Systems Assurance program, ensuring compliance with regulatory guidelines, leading validation activities, and supporting operational quality within a biotech environment.

Perform bioanalytical method development and LC-MS/MS quantitation for in vitro and in vivo ADME/DMPK studies, including MetID with LC-QTOF, PK sample analysis, CRO project management, data reporting, and maintaining electronic lab notebooks to support drug discovery programs.

Support the CHRO as a trusted executive partner by managing calendars, communications, approvals, travel, expenses, and confidential information. Plan and execute company events, employee experiences, and culture initiatives while coordinating stakeholders, vendors, budgets, and timelines. Contribute to HR special projects, build cross-functional relationships, and help promote an inclusive, connected workplace.

The Director of Regulatory Affairs develops global regulatory strategies and leads interactions with health authorities for clinical submissions, focusing on immunology and inflammation.

Lead quality oversight of global supply chain activities for clinical programs, ensuring GMP/GDP compliance across suppliers, CMOs, warehouses, and logistics. Manage supplier qualification, audits, deviation/CAPA investigations, shipping validations, and quality agreements while partnering with cross-functional teams to maintain timely, compliant supply of clinical materials.

Lead design and execution of in vitro pharmacology and screening workflows for Degrader Antibody Conjugates (DACs). Develop and run cellular assays characterizing DAC activity, maintain cell lines, interpret data, provide go/no-go recommendations, and partner cross-functionally to advance candidates. Mentor scientists and present findings to project teams and leadership.

Manage integrated project plans and partner governance for IND-enabling and early clinical programs. Coordinate cross-functional teams, maintain timelines, track risks/issues, drive decisions, manage meeting rhythms and action-item follow-up, and support resourcing, forecasting, and PM tool/process improvements.

Develop, optimize, and validate antibody bioconjugation chemistries scalable from bench to multi-mg production. Design automation-ready protocols, execute conjugation runs, purify and characterize conjugates (FPLC, TFF, HPLC, LC-MS), write SOPs and technical reports, train automation staff, and collaborate cross-functionally with chemistry, protein biochemistry, computational teams, and CROs/CDMOs.

Lead end-to-end IT infrastructure and operations including cybersecurity operations, end-user services, and ITSM. Consolidate MSPs, build a SOC, align research and scientific computing with IT, manage AWS/HPC/container environments, establish IAM, and improve vendor and service management.

Lead development of analytical workflows for degrader antibody conjugate (DAC) characterization. Design and execute assays (DAR, aggregation, protein quantitation, SEC, HIC, peptide mapping), establish QC thresholds, perform in-depth antibody/DAC characterization (positional isomers, glycosylation, stability), integrate data for go/no-go decisions, and communicate results to cross-functional teams.

Lead development and execution of global regulatory strategy for oncology (solid tumors), manage preparation of high-quality IND/CTA/NDA/MAA submissions, interact with health authorities, track submission deliverables, and guide cross-functional teams to mitigate regulatory risk and ensure compliance.