Chai Discovery Logo

Chai Discovery

Research Engineer

Reposted 29 Days Ago
In-Office
San Francisco, CA, USA
Mid level
In-Office
San Francisco, CA, USA
Mid level
The AI Engineer will develop and optimize AI models and high-performance software systems for drug discovery, collaborating with researchers and maintaining infrastructure.
The summary above was generated by AI
About Chai Discovery

Chai builds the design suite for molecules. We train frontier models that learn the underlying foundations of biochemical structure and interaction, so scientists can move faster and pursue targets that other methods cannot reach.

AI is reinventing life sciences the same way it reinvented software engineering, and Chai is at the forefront of this shift. Leading pharmaceutical companies like Eli Lilly, Pfizer, and Novartis are adopting our platform to power their drug discovery programs.

We value diverse perspectives and are ready to find greatness in unexpected places.

About the role

We are seeking an AI Research Engineer to help design, train, evaluate, and optimize Chai’s core models, working in tight loops with research scientists. Chai's models are moving beyond protein structure prediction into real-world therapeutic engineering. This is a chance to push the frontier of AI drug design, working alongside a craft-obsessed team of micro-pessimists and macro-optimists.

  • Develop and optimize all the compute & data systems upon which our research depends.

  • Build, run and continuously improve evals and data sources, continually improving the rigor and confidence of our methods.

  • Collaborate with AI researchers to execute experiments and pursue new research directions.

About you

Ideal backgrounds include high-performance computing, custom CUDA kernels and GPU programming, AI/ML + data systems at scale.

  • Bachelor’s or Master’s degree in Computer Science, Software Engineering, or a related field.

  • Strong proficiency in programming languages such as Python and deep learning frameworks like PyTorch.

  • Deep understanding of operating system internals.

  • Experience with HPC infrastructure such as Slurm and Kubernetes.

  • Experience with performance engineering and profiling for CPU and CPU workloads.

  • Experience writing, building, and maintaining large-scale ETL pipelines.

We offer

The opportunity to work at the vanguard of AI research and frontier biology, with world-class people, on a mission that matters. We protect & promote a culture of high velocity and ownership. We compensate our team accordingly.

HQ

Chai Discovery San Francisco, California, USA Office

San Francisco, California, United States

Similar Jobs

3 Days Ago
Hybrid
San Francisco, CA, USA
87K-168K Annually
Junior
87K-168K Annually
Junior
Fintech • Financial Services
Conduct penetration testing of web, mobile, and API applications using manual techniques and automated DAST tools. Analyze and validate vulnerabilities, triage false positives, produce technical reports, and collaborate with development and security teams on remediation. Configure scanners, apply AI-assisted security analysis responsibly, improve testing methodologies, and communicate findings to stakeholders while maintaining compliance with security, privacy, and ethical standards.
Top Skills: Ai-Enhanced Security ScannersAPIsAppscanBurp SuiteDynamic Application Security Testing (Dast)FiddlerGdprInvictiMobile ApplicationsOwasp Top 10Pci DssPythonShellWeb ApplicationsWebinspect
12 Days Ago
Hybrid
Santa Clara, CA, USA
203K-354K Annually
Senior level
203K-354K Annually
Senior level
Artificial Intelligence • Cloud • HR Tech • Information Technology • Productivity • Software • Automation
Lead research in agent learning and recursive self-improvement for enterprise AI agents. Design post-training methods, agent harnesses, training environments, evaluations, and distributed pipelines across language and multimodal systems. Analyze failures, develop training signals, run rigorous experiments, and transition validated improvements into reliable production systems. Collaborate with research, engineering, infrastructure, security, and product teams while communicating results through publications, patents, reports, and open-source work.
Top Skills: DeepspeedFsdpKubernetesMcpMegatronOpenrlhfPythonPyTorchPytorch DistributedRaySglangSlurmTrlVerlVllm
13 Days Ago
Hybrid
Santa Clara, CA, USA
232K-405K Annually
Senior level
232K-405K Annually
Senior level
Artificial Intelligence • Cloud • HR Tech • Information Technology • Productivity • Software • Automation
Lead high-impact research in agent learning and recursive self-improvement. Design post-training methods, agent harnesses, training environments, evaluations, and distributed pipelines for reliable enterprise agents. Investigate planning, reasoning, memory, tool use, multimodal capabilities, and long-horizon execution. Analyze failures, run rigorous experiments, build improvement loops, and transition validated research into production systems. Provide technical leadership across teams and communicate results through reports, publications, patents, benchmarks, and open-source contributions.
Top Skills: Distributed InferenceDistributed TrainingDpoGpu InfrastructureGrpoKnowledge RetrievalLarge Language Models (Llms)Model Context Protocol (Mcp)Multimodal ModelsPythonPyTorchReinforcement LearningReward ModelingSupervised Fine-Tuning (Sft)

What you need to know about the San Francisco Tech Scene

San Francisco and the surrounding Bay Area attracts more startup funding than any other region in the world. Home to Stanford University and UC Berkeley, leading VC firms and several of the world’s most valuable companies, the Bay Area is the place to go for anyone looking to make it big in the tech industry. That said, San Francisco has a lot to offer beyond technology thanks to a thriving art and music scene, excellent food and a short drive to several of the country’s most beautiful recreational areas.

Key Facts About San Francisco Tech

  • Number of Tech Workers: 365,500; 13.9% of overall workforce (2024 CompTIA survey)
  • Major Tech Employers: Google, Apple, Salesforce, Meta
  • Key Industries: Artificial intelligence, cloud computing, fintech, consumer technology, software
  • Funding Landscape: $50.5 billion in venture capital funding in 2024 (Pitchbook)
  • Notable Investors: Sequoia Capital, Andreessen Horowitz, Bessemer Venture Partners, Greylock Partners, Khosla Ventures, Kleiner Perkins
  • Research Centers and Universities: Stanford University; University of California, Berkeley; University of San Francisco; Santa Clara University; Ames Research Center; Center for AI Safety; California Institute for Regenerative Medicine

Sign up now Access later

Create Free Account

Please log in or sign up to report this job.

Create Free Account