Director, IT Infrastructure

The Position

The Director of IT Infrastructure is a leadership role responsible for the strategy, design, implementation, and ongoing operations of the company’s enterprise IT infrastructure. This leader will oversee a geographically distributed environment spanning on-premises and public cloud platforms (Microsoft Azure and Amazon Web Services). The Director will lead a team of infrastructure staff to support business needs, drive modernization initiatives, and ensure the reliability and scalability of all infrastructure services in alignment with pharmaceutical industry standards.

This role is based onsite 5 days a week from one of Arrowhead's office locations. 

Responsibilities

• Define and execute a multi-year IT infrastructure roadmap aligned with corporate growth objectives and digital transformation priorities.
• Lead, mentor, and develop a high-performing infrastructure team across multiple sites.
• Partner with the IS leadership and business stakeholders to align infrastructure investments with organizational priorities and compliance requirements.
• Establish and manage infrastructure budgets, vendor contracts, and technology refresh cycles.
• Develop and communicate infrastructure KPIs, SLAs, and operational metrics to IS leadership.
• Define and execute a multi-year IT infrastructure roadmap aligned with corporate growth objectives and digital transformation priorities.
• Oversee the design, deployment, and lifecycle management of virtualization infrastructure across all company locations.
• Manage a Microsoft Active Directory environment
• Drive hybrid cloud strategy and operations across Azure and AWS, optimizing workload placement, cost, and performance.
• Ensure high availability, disaster recovery, and business continuity capabilities for all critical infrastructure components.
• Oversee network infrastructure including LAN/WAN and SD-WAN connectivity across all company sites and cloud tenants.
• Oversee server patching and configuration management standards across the enterprise.
• Lead capacity planning and performance monitoring to ensure infrastructure scalability in support of business growth.
• Ensure all infrastructure platforms and processes comply with regulatory requirements as applicable.
• Support internal and external audits by providing documentation, evidence, and technical guidance related to infrastructure controls.
• Maintain and test disaster recovery and incident response plans in partnership with IS and business teams.
• Lead infrastructure-related projects from inception through delivery, including consolidations, cloud migrations, and site expansions.
• Manage relationships with key technology vendors and MSPs, negotiating contracts and ensuring service delivery accountability.
• Evaluate and recommend emerging technologies that drive operational efficiency and cost reduction.

Requirements

• Bachelor's degree in Computer Science, Information Systems, Information Technology, or a related field.
• 10+ years of progressive IT infrastructure experience, with at least 4 years in a senior leadership or director-level role.
• Deep hands-on expertise with virtualization platforms (VMware, Nutanix, Hyper-V).
• Demonstrated experience managing Microsoft Active Directory.
• Strong working knowledge of AWS and Azure — architecture, operations, cost management, and security.
• Experience managing multi-site enterprise IT environments in a regulated industry.
• Proven track record of building, leading, and developing high-performing infrastructure teams.
• Strong understanding of network architecture, security principles, and ITIL-based service management frameworks.
• Experience with infrastructure compliance frameworks relevant to pharma/biotech (GxP, SOX, HIPAA).

Preferred

• Current or previous industry certifications such as VMware VCP/VCAP, Azure Administrator/Architect, AWS Solutions Architect, or ITIL v4.
• Experience with infrastructure-as-code tools such as Terraform, Ansible, or Bicep.
• Experience supporting laboratory and manufacturing IT environments (OT/IT convergence) within a pharmaceutical or life sciences setting.
• Strategic thinking and the ability to translate business needs into scalable infrastructure solutions.
• Strong communication skills - able to present complex technical topics clearly to non-technical audiences.
• Exceptional organizational and prioritization skills in a fast-paced, regulated environment.
• Collaborative leadership style with a strong emphasis on team development and cross-functional partnership.
• Data-driven decision-making and a continuous improvement mindset.