Life Cycle Leader for Pegozafermin (MASH)

Who we are

At Roche, we are passionate about transforming patients’ lives, and we are bold in both decision and action - we believe that good business means a better world. That is why we come to work every single day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow. Roche is strongly committed to a diverse and inclusive workplace. We strive to build teams that represent a range of backgrounds, perspectives, and skills. Embracing diversity enables us to create a great place to work and to innovate for patients.

The Opportunity

Our Global Pharma Strategy (GPS) team plays a pivotal role in shaping the future of healthcare by driving the strategic direction of our innovative product portfolio. As a member of the GPS team, you will be at the forefront of transforming groundbreaking scientific discoveries into accessible and impactful healthcare solutions for patients worldwide. We are seeking a dynamic and visionary professional who thrives in a collaborative environment and is passionate about making a difference.

About The Position

You will be responsible for our Pegozafermin asset, currently in Phase 3 for the treatment of MASH. Pegozafermin (FGF-21 analog) is our latest portfolio addition following the acquisition of 89Bio. Data readouts are expected from 2027, with the first filing expected soon after. Pegozafermin could be among the first launches in CVRM for Roche and represents a treatment option addressing significant unmet needs in a population with very limited current treatment options.

The CVRM Team

Cardiovascular, Renal, and Metabolism (CVRM) is a new and important therapy area at Roche. We are building a broad and deep pipeline of assets with the potential to significantly impact people living with chronic diseases across obesity, diabetes (Type 1 and Type 2), MASH, and cardiovascular diseases (HTN, ASCVD, etc.). As a team, we hold overall accountability for late-stage assets by leading and connecting the organization via asset-specific life cycle teams. We also provide strategic insights and guidance to research and early development for internal and external innovation in the CVRM space. We pride ourselves on understanding the external ecosystem and competitive environment to develop impactful strategies that will advance standards of care and become best-in-disease/class medicines upon launch. We aim to challenge the status quo, empower patients to achieve their full potential in life, and know that every step counts.

Key Responsibilities

• Lifecycle excellence: ability to extend the assets potential by evaluating and triggering different value levers

• Value earlier: Flex earlier in the lifecycle to create seamless transition from early to late stage (e.g. provide relevant input into the one asset team at critical time points such as piv enabling CDP)

• Lead molecule optimization within and across relevant therapeutic areas to ensure critical decisions are made which could impact value capture, including but not limited to device, diagnostics and digital ecosystem build

• Shaping the long-term vision and strategy for one or several molecule programs – which can be large and/or complex in partnership with early development, Pharma Development, Global Pharma Strategy, Pharma Development Medical Affairs leads and respective external partners

• Supporting relevant early development asset teams, licensing, and other business development activities.

• Strong collaboration with the Global Development Team and  Commercial Leadership Team to realize the potential of the asset.

• Serving as a thought partner and sounding board for the GPS teams and relevant internal and external stakeholders, ensuring that franchise and enterprise goals are met

• Serving as an inspiring leader, aligning people towards a vision while building a culture of accountability, collaboration,  inclusion, and trust.

Who You Are

• Educational Background: A Bachelor's Degree is required, preferably in a marketing, business management, or life sciences discipline. MD, PhD, or other relevant Graduate, Postgraduate Degree or MBA  (depending on the Lifecycle of the product) and TA experience are preferred.

• Substantial Experience: Demonstrable previous accomplishments should include developing and overseeing the execution of breakthrough development and/or commercial strategies that led to considerable financial results. You need extensive experience in launch planning and management, as well as an ability to quickly develop a deep understanding of global health systems, access and reimbursement challenges, and product life-cycle planning.

• Strategic & Global Leadership: The role requires outstanding leadership skills with a proven track record in building teams and the ability to influence in a cross-functional environment. You should have exceptional strategic orientation and agility, with an outstanding ability to develop a long-term vision and a deep understanding of the global pharmaceutical/biotechnology industry to create robust and innovative business strategies.

Preferred Candidate Profile

• The ideal candidate has relevant disease area experience and understands the unique opportunities and challenges in MASH. You have demonstrated your ability to lead large teams across the full value chain in previous roles and effectively navigate large matrix organizations. 

• You lead by example, inspire teams to challenge the status quo, and thrive in a dynamic, high-paced environment. You are a strategic thinker focused on strategy execution and take pride in defining clear priorities and formulating strategic choices that will give us an edge against the competition and ensure relevance for patients and health systems. 

• You enjoy a good scientific discussion, understand value chain complexities, and have the drive and ambition to deliver outstanding commercial performance. Lastly, you are a team player who contributes to creating an inclusive and informal culture. 

• You care for your colleagues, dare to speak up, and do not take yourself too seriously.

What success looks like in the role:

• Maximizing Value: Success is achieved by maximizing the product's lifecycle value to patients, society, and the company.

• Execution and Financial Targets:  Ensuring the timely, on-target, and within-budget delivery of the product strategy, including meeting key milestones and financial targets for the product.

• Leadership and Accountability: A key measure of success is the ability to effectively develop a high performing team by influencing internal and external stakeholders.

Join us in our mission to advance science and deliver hope to those who need it most.

Location

The primary location is South San Francisco with additional locations being Boston and Basel, Switzerland.

Relocation assistance is available for this position.

Compensation

The expected salary range for this position based on the primary location of South San Francisco, is $346,800/yr to $455,175/yr.  Actual pay will be determined based on experience, qualifications, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance.  This position also qualifies for the benefits detailed at the link provided below.

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Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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