Manager, NGS Operations

POSITION SUMMARY: 

The Manager, NGS Operations oversees lab personnel and daily operations of sequencing instruments in support of research and development projects. The ideal candidate is both technically proficient and people-focused, able to balance hands-on problem solving with mentoring and developing a high-performing team.

 PRIMARY RESPONSIBILITIES: 

• Manage daily scheduling and oversight of employees performing next generation sequencing (NGS) while fostering a collaborative, accountable, and growth-oriented team culture
• Manage Illumina sequencing workflows (NovaSeq X, Novaseq 6000, MiSeq i100, etc.)
• Monitor run level performance metrics (error rate, %Q30, cluster pass filter, % occupancy, etc) and troubleshoot instrument or library issues as needed 
• Oversee PacBio Sequel and Revio operations, including instrument loading, run setup, and monitoring of key performance metrics (e.g., read length distribution, yield, accuracy/Q-scores), and troubleshoot instrument or library-related issues as needed
• Lead continuous improvement initiatives to optimize throughput, reduce turnaround times, and minimize errors, balancing speed with quality
• Serve as the primary point of contact for sequencing-related questions and workflow decisions, communicating clearly and proactively with stakeholders
• Maintain accurate records of lab work, ensure compliance with SOPs, and champion best practices in documentation and process adherence
• Collaborate closely with peer groups in Scientific Operations to align sample processing and sequencing workflows with project goals
• Provide hands-on support for troubleshooting and workflow optimization, while coaching team members to develop independence and confidence in their technical problem-solving
• Present team activity summaries, project updates, and performance metrics to management, highlighting successes, challenges, and opportunities for innovation
• Contribute to budget planning, capital equipment purchases, and vendor management for sequencing platforms and consumables, ensuring resources meet both current and future needs

QUALIFICATIONS:

• BS/BA in a biological science or equivalent required; advanced degree preferred
• 5 years of related experience, 2+ years in a supervisory or leadership role

KNOWLEDGE, SKILLS, AND ABILITIES:

• Hands-on experience with library preparation and next generation sequencing platforms, including Illumina (NovaSeq 6000, NovaSeq X, MiSeq i100) and PacBio (Sequel, Revio)
• Hands-on experience with nucleic acid techniques (isolation, purification, sonication, quantification, ampification, hybridization capture, etc.)
• Familiarity with laboratory automation a plus (Hamilton, Tecan, Biomek, Qiasymphony)
• Able to recognize lab issues and team concerns, communicate to management, and suggest improvements
• Knowledge of LIMS/database software
• Proficiency with Microsoft Office and Google Drive programs
• Excellent oral and written communication skills
• Ability to think creatively and analytically with strong troubleshooting and problem-solving skills
• Strong leadership and mentoring skills with a proven ability to motivate and develop technical staff
• Experience managing vendor contracts and evaluating technology platforms for lab implementation
• Ability to thrive in a fast-paced, evolving environment, and manage competing priorities efficiently