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SignalFire

Principal AI/ML Engineer - VC Backed Startups

Sorry, this job was removed at 06:15 p.m. (PST) on Tuesday, Nov 11, 2025
In-Office
6 Locations
170K-270K Annually
In-Office
6 Locations
170K-270K Annually

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Join SignalFire’s Talent Network for Principal AI/ML Engineer Roles at VC-Backed Startups

🛑 This is not an application for a specific job. Instead, this is a way to get on the radar of VC-backed startups that are actively hiring AI/ML talent. If you have any questions, please direct inquiries to [email protected].

At SignalFire, we partner with top early-stage startups that are shaping the future of technology. Our portfolio spans 200+ innovative companies across AI, cybersecurity, healthtech, fintech, developer tools, and enterprise SaaS.

We’re looking to connect with exceptional Principal AI/ML Engineers who are excited about driving AI strategy, advancing machine learning research, and scaling AI-powered systems at high-growth startups. By joining SignalFire’s Talent Network, your profile will be shared with our portfolio companies, giving you visibility into exclusive early-stage opportunities that may not be publicly listed.

Who Should Join?

We’re looking for AI/ML experts who are:
✔ Passionate about developing and deploying cutting-edge machine learning and deep learning models
✔ Experienced in architecting scalable AI systems and leading technical teams
✔ Excited to push the boundaries of AI research and apply it to real-world business challenges

Typical Roles & Responsibilities
  • Architect, develop, and optimize machine learning and deep learning models for production systems

  • Research and apply state-of-the-art AI methodologies, including LLMs, transformers, and reinforcement learning

  • Lead AI strategy, identifying opportunities for innovation and model optimization

  • Develop scalable training and inference pipelines for AI-powered applications

  • Work closely with engineering, data, and product teams to integrate AI/ML into business solutions

  • Optimize ML models for efficiency, accuracy, and scalability in real-world deployments

  • Ensure robust MLOps practices, including model monitoring, retraining, and deployment automation

  • Collaborate on AI/ML research publications, patents, and open-source contributions

Common Qualifications

While each startup has its own hiring criteria, many Principal AI/ML Engineer roles in our network look for:

  • 8+ years of experience in AI/ML, deep learning, or applied AI

  • Expertise in Python and ML frameworks (TensorFlow, PyTorch, JAX, Hugging Face Transformers)

  • Strong background in computer vision, NLP, generative AI, or reinforcement learning

  • Experience developing scalable AI pipelines, data processing workflows, and distributed training systems

  • Familiarity with big data tools (Apache Spark, Kafka, Hadoop) and MLOps platforms (MLflow, TFX, SageMaker)

  • Deep understanding of LLMs, transformer architectures, and retrieval-augmented generation (RAG) pipelines

  • Experience with model quantization, fine-tuning, and optimization for performance

  • Strong knowledge of cloud environments (AWS, GCP, Azure) and containerization tools (Docker, Kubernetes)

  • A track record of technical leadership, mentoring, and driving AI innovation

💡 Technologies You Might Work With:
  • Languages & Frameworks: Python, TensorFlow, PyTorch, JAX, Hugging Face Transformers

  • MLOps & Data Pipelines: MLflow, Kubeflow, TFX, Apache Spark, Airflow, Ray

  • Cloud & Deployment: AWS SageMaker, GCP Vertex AI, Azure ML, Kubernetes, Docker

  • Big Data & Storage: Apache Kafka, Hadoop, BigQuery, Snowflake, Redis, NoSQL databases

  • Model Optimization: ONNX, TensorRT, pruning, quantization, distillation

What Happens Next?
  1. Submit your application to join SignalFire’s Talent Ecosystem.

  2. We review applications on an ongoing basis to identify strong candidates.

  3. If there’s a match, a SignalFire talent partner or a leader from one of our startups may reach out directly.

  4. No match yet? We’ll keep your profile on file for future AI/ML roles in our portfolio.

HQ

SignalFire San Francisco, California, USA Office

501 2nd St, 100, San Francisco, CA, United States, 94107

What you need to know about the San Francisco Tech Scene

San Francisco and the surrounding Bay Area attracts more startup funding than any other region in the world. Home to Stanford University and UC Berkeley, leading VC firms and several of the world’s most valuable companies, the Bay Area is the place to go for anyone looking to make it big in the tech industry. That said, San Francisco has a lot to offer beyond technology thanks to a thriving art and music scene, excellent food and a short drive to several of the country’s most beautiful recreational areas.

Key Facts About San Francisco Tech

  • Number of Tech Workers: 365,500; 13.9% of overall workforce (2024 CompTIA survey)
  • Major Tech Employers: Google, Apple, Salesforce, Meta
  • Key Industries: Artificial intelligence, cloud computing, fintech, consumer technology, software
  • Funding Landscape: $50.5 billion in venture capital funding in 2024 (Pitchbook)
  • Notable Investors: Sequoia Capital, Andreessen Horowitz, Bessemer Venture Partners, Greylock Partners, Khosla Ventures, Kleiner Perkins
  • Research Centers and Universities: Stanford University; University of California, Berkeley; University of San Francisco; Santa Clara University; Ames Research Center; Center for AI Safety; California Institute for Regenerative Medicine

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