Principal Bioinformatician, Precision Oncology

Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

Company Overview:

Tempus is a leading biotechnology company dedicated to advancing precision medicine through

the development and commercialization of innovative diagnostic products. We are seeking a

highly skilled and motivated Principal Bioinformatics Scientist to join our research &

Development team working on cutting edge technologies for precision oncology, focusing in

the near term on measuring Minimal Residual Disease (MRD) and Treatment Response Monitoring (TRM). Tempus has launched, and will continue to expand, both tumor-informed and tumor-naive MRD assays. We will also incorporate multimodal algorithms to discern patients at high risk of progression or relapse (MRD+, high-risk). This position offers an exciting opportunity to make a significant impact in the field of precision oncology and contribute to improving patient outcomes. 

Key responsibilities

• Algorithm Development: Designing, implementing, and validating cutting-edge algorithms and statistical models, including deep learning approaches, for analyzing large-scale genomic and epigenomic datasets.

• Multimodal Data Analysis: Analyze and interpret complex multimodal data from techniques like next-generation sequencing (NGS), including methylation, DNA, and RNA, to derive insights for MRD and TRM.

• Scalable Pipeline Development: Developing and maintaining robust bioinformatics pipelines for processing and analyzing NGS data within high-performance computing environments.

• Collaboration: Working closely with molecular biologists, other bioinformaticians, engineering and cross-functional teams to answer biological questions and drive the development and launch of assays and algorithms.

• Leadership: Provide technical vision and strategic direction for bioinformatics projects, managing research initiatives from concept to commercialization and ensuring alignment with organizational goals.diagnostic products for clinical and research purposes, particularly those related to MRD.

• Documentation and Communication: Producing high-quality documentation for projects and communicating results effectively to scientific teams and leadership.

• Mentorship: Leading, mentoring, and training other scientists and engineers within the team.

• Innovation: Stay abreast of the latest advancements in AI/ML, genomics, and precision medicine, driving the incorporation of new methodologies into products and workflows. 

Essential skills and qualifications

• Advanced Degree: Ph.D. in Bioinformatics, Computer Science, or a related analytical field with a focus on cancer genomics.

• Extensive Experience: 8+ years of extensive experience in an industry or academic setting, with a strong background in high-throughput sequencing analysis, algorithm development, and data science.

• AI/Machine Learning Expertise: A deep understanding of core ML concepts and algorithms, including supervised, unsupervised, and reinforcement learning. Hands-on experience with major deep learning frameworks such as PyTorch or TensorFlow. Experience with advanced architectures like Transformers or CNNs is highly desirable.

• Computational Skills: Strong programming skills in languages like Python and R, along with experience using contemporary tools for processing and analyzing NGS data.

• Genomics Domain Knowledge: In-depth knowledge of genomics, molecular diagnostic technologies, and cancer biology, particularly in the context of liquid biopsy and MRD.

• Statistical Modeling: Strong understanding of statistical modeling and the ability to develop predictive or prognostic algorithms.

• Leadership and Communication: Proven leadership abilities, excellent communication skills (both written and oral), strong interpersonal skills, and the ability to collaborate effectively in interdisciplinary teams.

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The expected salary range above is applicable if the role is performed from California and may vary for other locations (Colorado, Illinois, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.

We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.