Conducts mRNA display and DNA-encoded library screening for cyclic peptide and small-molecule discovery. Responsibilities include designing and analyzing selections, optimizing platform workflows, handling nucleic acids, developing hit-identification assays, analyzing sequencing data, and supporting client projects. The role also contributes to peptide characterization, project planning, documentation, platform innovation, and technology transfer in a biotech or contract research environment.
Overview
We are looking for a Research Scientist with deep expertise in peptide chemistry and chemical biology to help shape and deliver our mRNA display & DNA encoded libraries (DEL) services for external clients. You will work independently on peptide and small molecule discovery projects, refine and work on internal Research & Development. This is a hands-on, scientifically demanding role at the interface of chemistry, molecular biology and client delivery. You will work with a collaborative team of scientists, contribute to platform innovation, and work closely with external partners.
Responsibilities- Design, run and analyze mRNA display selections of cyclic peptide libraries against diverse targets
- Maintain, optimize and extend the mRNA display platform, including library design, translation, cyclisation and selection workflows
- Handle and quality-control nucleic acids (mRNA, DNA, cDNA), including library preparation, PCR/RT-PCR and next-generation sequencing readouts
- Develop, validate and transfer assays for hit identification and confirmation
- Contribute to project planning, timelines and documentation
- Keep abreast of new developments in display technologies and cyclic peptide therapeutics, and propose improvements to our offering
- Contribute to peptide and small-molecule DEL screening projects, including library screening, hit identification and data analysis
- Master in chemistry, chemical biology, biochemistry or equivalent experience
- Proven experience in mRNA display, including screening of cyclic peptide libraries and platform manipulation
- Strong practical skills in nucleic acid handling (mRNA/DNA work, PCR, library construction, sequencing analysis)
- Experience developing and optimizing assays for hit identification and validation
- Excellent written and spoken English
Additional Skills
- Experience in In Vitro peptide macrocyclization, bioconjugation & genetic code reprogramming
- Biophysical assays for binding and affinity (e.g. SPR, BLI, ITC, FP)
- Peptide characterization by LC-MS, HPLC and related analytical methods
- Industry experience in a biotech, pharmaceutical or contract research / service environment, with an understanding of timelines, quality expectations and client delivery
- Experience with DNA encoded libraries
Similar Jobs
Artificial Intelligence • Fintech • Information Technology • Logistics • Payments • Business Intelligence • Generative AI
Leads regional partner strategy and indirect sales growth through resellers and strategic alliances. Responsibilities include partner-led pipeline generation, enterprise deal execution, forecasting, account planning, QBRs, partner onboarding and enablement, events, executive engagement, and performance analysis. The role collaborates closely with Coupa sales teams to drive revenue, manage deal progression, and strengthen partner relationships.
Top Skills:
ClariEnterprise SoftwareSalesforceTotal Spend Management Platforms
Artificial Intelligence • Healthtech • Machine Learning • Natural Language Processing • Biotech • Pharmaceutical
Leads Pfizer’s medical channel excellence team and develops global omnichannel strategies for scientific engagement across therapeutic areas. Oversees audience journeys, digital and social channels, paid media, vendor relationships, budgets, regulatory alignment, and channel performance. Partners with Medical Affairs, R&D, Evidence Generation, legal, compliance, and global teams to disseminate scientific content to healthcare professionals. Provides strategic leadership, manages resources, develops channel infrastructure, and drives innovation in personalized medical communications.
Top Skills:
Digital PlatformsOmnichannel Engagement PlatformsScientific Content Dissemination ToolsSocial Media ChannelsThird-Party Digital Platforms
Artificial Intelligence • Cloud • Computer Vision • Hardware • Internet of Things • Software
As an Account Development Representative at Samsara, you will generate business opportunities through outbound outreach, support the sales team, and learn about various industries. The role focuses on building buyer relationships and requires excellent communication skills, motivation, and resilience.
Top Skills:
LushaSalesforceSalesloft
What you need to know about the San Francisco Tech Scene
San Francisco and the surrounding Bay Area attracts more startup funding than any other region in the world. Home to Stanford University and UC Berkeley, leading VC firms and several of the world’s most valuable companies, the Bay Area is the place to go for anyone looking to make it big in the tech industry. That said, San Francisco has a lot to offer beyond technology thanks to a thriving art and music scene, excellent food and a short drive to several of the country’s most beautiful recreational areas.
Key Facts About San Francisco Tech
- Number of Tech Workers: 365,500; 13.9% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Google, Apple, Salesforce, Meta
- Key Industries: Artificial intelligence, cloud computing, fintech, consumer technology, software
- Funding Landscape: $50.5 billion in venture capital funding in 2024 (Pitchbook)
- Notable Investors: Sequoia Capital, Andreessen Horowitz, Bessemer Venture Partners, Greylock Partners, Khosla Ventures, Kleiner Perkins
- Research Centers and Universities: Stanford University; University of California, Berkeley; University of San Francisco; Santa Clara University; Ames Research Center; Center for AI Safety; California Institute for Regenerative Medicine
