Scientist I, Chemoproteomics

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life’s moments for children and adults living with a rare disease.

At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging.

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Job Description Summary:

PTC Therapeutics is seeking an innovative and motivated scientist to join our Multiomics team in Mountain View, CA. The successful candidate will develop and apply chemoproteomic methods to advance drug discovery programs and translational biomarker strategies. We are looking for someone to join our group who is: organized, methodical, team-oriented, and not afraid to tackle challenging problems. The ideal candidate will be a technical expert in proteomics and have broad knowledge of biological processes associated with either: neurodegenerative/neuromuscular disorders, inflammation, immunology, or ferroptosis.
The Scientist I is responsible for the detailed planning and execution of scientific experiments under the guidance of the Executive Director of Multiomics. The incumbent works in matrixed teams and serves as a subject matter expert for programs advancing PTC’s research and drug discovery activities.
The Scientist I supports adherence to relevant regulatory requirements and internal Standard Operating Procedures (SOPs) as appropriate.Job Description:

ESSENTIAL FUNCTIONS

Primary duties/responsibilities:

• Sample processing and enrichment of multiple sample types (e.g. plasma, CSF, tissues, and cells) for downstream proteomics analysis using a variety of techniques including, but not limited to: ultracentrifugation, SP3, SAX, RP/C18, IMAC/MOAC, SEC, FASP, IP, co-IP, etc.

• Daily operation of nano-LC (i.e. Evosep and nano-Elute) instruments as well as ion-mobility and high-resolution mass spectrometers (i.e. Bruker tims-ToF and Thermo Orbitrap).

• Use of label-free chemoproteomic techniques like LiP and TPP as well as directed proteomic analyses such as ABPP or PAL.

• Execution of quantitative proteomic workflows using TMT, SILAC, spiked-in isotopically labeled standards, or PRM analysis.

• Analysis of proteomic datasets using Spectronaut, MS Fragger, DIA-NN, Skyline, etc.

• Integrates multiomic datasets and uses pathway analyses to correlate observed changes with disease phenotype, treatment effect, or translational biomarker identification.

• Communicates effectively and cooperates with cross-functional teams to plan and execute strategies to achieve program and corporate goals.

• Tracks daily progress in Agile software to provide real-time updates for project stakeholders.   

• Represents the organization in external collaborations and at scientific conferences. May participate in the authorship and publication of scientific papers and patents.

• Interviews and evaluates potential new hires. Acts as a resource for and trains junior staff.

• Abides by all safety and regulatory guidelines. Maintains a detailed laboratory notebook.

• Contributes to general lab needs such as: equipment maintenance, evaluation of capital equipment purchases, and authorship/development of Standard Operating Procedures (SOPs).

• Performs other tasks and assignments as needed and specified by management.

KNOWLEDGE/SKILLS/ABILITIES REQUIRED

• Experience in maintaining and troubleshooting nano-LC instruments as well as ion-mobility or high-resolution mass spectrometers.

• Extensive use of sample preparation and enrichment strategies for chemoproteomics, global proteomics, and PTM analysis.

• Expertise in using proteomic software tools for ID, statistics, pathway analysis, and visualization.

• Detail-oriented and organized with excellent problem-solving skills.

• Self-motivated and also a team player.

• Proactive communicator with a positive attitude.

• Ability to multitask and respond quickly to shifting priorities while adhering to program timelines.

* Minimum level of education and years of relevant work experience.

• Ph.D. in Analytical Chemistry, Chemical Biology, Biochemistry, or Biomedical Engineering with 4 – 5 years of relevant experience (including doctoral…).

* Special knowledge or skills needed and/or licenses or certificates required.

• Hands-on use of Bruker tims-ToF instruments running DIA-PASEF, PRM-PASEF, and diagonal-PASEF.

• Previous use of Evosep systems run at ≥ 100spd or prior use of the Bruker nano-Elute LC.

• Expertise using proteomic software tools such as: Spectronaut, MS Fragger, DIA-NN, etc.

*Special knowledge or skills and/or licenses or certificates preferred.

• Prior use of Mass Dynamics software.

• Coding experience is a plus.

* Travel requirements

• Up to 10%

• Office/Laboratory based position

Expected Base Salary Range: $119,300 - $142,000.The base salary offered will be contingent on the assessment of the candidate's education level, background, and experience relative to the requirements of the position they are being considered for, as well as a review of internal equity.

 

In addition to base salary, PTC employees are also eligible for short- and long-term incentives. All eligible employees may also enroll in PTC’s medical, dental, vision, and retirement savings plans.

EEO Statement:

PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.

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