Scientist I – In vitro ADME

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

Nurix is currently seeking a Scientist I, DMPK with expertise in vitro ADME assays. You will use your expertise to execute in vitro studies to elucidate the absorption, distribution, metabolism, excretion (ADME) properties of our small molecule targeted protein degrader drug candidates.

Working closely with the in vitro ADME team and Medicinal Chemistry, the successful candidate will provide high quality in vitro ADME data in a timely manner to support drug screening, structure activity relationship, and to identify and advance small molecule lead drug candidates.

Key Responsibilities

• Perform routine in vitro experiments to address project specific questions related to compound metabolism and interaction with enzymes/transporters. The candidate will spend a majority of their time in the lab conducting experiments.
• Interpret data independently, troubleshoot, and upload high quality data to Nurix database in a timely manner.

• Manage the execution and quality of experiments and studies at external laboratories; review and evaluate protocols, results, and reports prior to reporting internally.
• Manage high quality routine in-house in vitro ADME studies as well as establish new assays to support drug candidate selection in a fast-paced environment, while managing multiple projects and various timelines.
• Perform enzymology studies, including CYP and non-CYP phenotyping and assessing their contribution in the catalysis for metabolite formation, determination of kinetic parameters including KM, Vmax, Ki and possible implications to drug-drug interactions.

• Maintain excellent records and documentation of the assays performed and the data generated.
• Perform analytical LC-MS/MS method development, bioanalysis, and instrumentation troubleshooting.

Preferred Qualifications & Experience

• Typically 0-4 years related experience (PhD), 4-6 years related experience (MS), or 8-10 years related experience (BS) in an industry setting
• Experience performing and interpreting high quality in vitro ADME studies, including but not limited to, metabolic stability, permeability, protein binding, enzyme induction/inhibition, transporter assays and drug interaction assessments.
• Hands-on experience with LC-MS sample analysis (ideally Sciex platform)
• Prior experience in executing hypothesis driven assays to address specific mechanistic ADME-related questions
• Experience investigating molecules in the beyond rule-of-5 (bro5) property space is desirable

Minimum Requirements

• Prior experience working within a discovery-driven pharmaceutical company
• Technical understanding and experience executing and troubleshooting in vitro ADME assays using cells, subcellular fractions, and other biological matrices (e.g. plasma, blood)
• Prior experience managing third parties and external service providers (worldwide) and consultants is preferred.
• Excellent organizational skills and laboratory notebook maintenance

• Experience with developing LC-MS/MS analytical methods and troubleshooting LC-MS instrumentation
• Fluency in data analysis and visualization software: Excel, GraphPad Prism, Sciex OS

• Strong interpersonal, communication, problem solving, and collaborative qualities to deliver high quality results in a fast-paced environment.
• Be self-driven and enthusiastic with the ability to thrive in a dynamic environment.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).