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Eli Lilly and Company

Senior Principal Scientist (R4)

Sorry, this job was removed at 06:17 p.m. (PST) on Tuesday, May 12, 2026
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In-Office
San Francisco, CA, USA
113K-187K Annually
In-Office
San Francisco, CA, USA
113K-187K Annually

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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Eli Lilly and Company seeks a Senior Principal Scientist (R4) to plan and implement experiments using in vitro assays and technologies to support drug discovery. Plan and implement experiments using biomedical assays, including absorbance and fluorescence-based assays including HTRF, AlphaScreen/Lisa, and Polarization, as well as cell assays with engineered cell lines. Support pioneering small molecule discovery and support SAR for multiple projects through their data and analysis within a multidisciplinary team. Generate high-quality, reproducible data by leveraging liquid handling, laboratory automation, and advanced data analysis tools. #LI-DNI
Position requires a Master’s degree in Biochemistry, Biology, or a related field, and 3 years of experience with biochemical assays, mammalian cell culture, and assay development. Experience must include a minimum of: 3 years of experience with liquid handling systems and automation, including Biomek, Hamilton, ECHO, and Integra; 3 years of experience with data analysis software, including GraphPad Prism or Dotmatics; and 3 years of experience with protein interaction technologies, including: HiBiT, AlphaLisa, and BLI. 5% domestic travel required. #LI-DNI

Job location: South San Francisco, CA.
To apply, please visit https://jobsearch.lilly.com/ and enter job requisition number R-103514 when prompted. Alternatively, please send your resume, cover letter, and a copy of the ad to: Matthew Tenaglio, Lilly Corporate Center, Indianapolis, IN 46285.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.


Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$112,549.00 - $187,000.00 per year

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

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