Senior RA/Associate Scientist

If you’re a Senior Research Associate or Associate Scientist with hands‑on antibody discovery experience and a drive to advance new therapeutics, we’d love to hear from you!

Join Us at Oxford Biotherapeutics (OBT)

Oxford Biotherapeutics (OBT) is a clinical‑stage biotechnology company developing innovative antibody‑based therapeutics for the treatment of cancer. You will contribute directly to the pre‑clinical development of our immuno‑oncology pipeline.

Our proprietary OGAP® platform, the world’s largest cancer‑specific membrane protein library enables the discovery of novel, highly tumour‑specific antigens for first‑in‑class ADC, Bispecific T‑cell Engager (BITE®), and CAR‑based therapeutics. Our lead asset, OBT076, is in Phase 1b clinical development, supported by a strong internal and partnered pipeline with leaders such as Roche, Boehringer Ingelheim, and Zymeworks.

Learn more at www.oxfordbiotherapeutics.com.

About the Role 

The Antibody Discovery Research Associate will support early-stage therapeutic and tool antibody programs by performing experiments that contribute to antibody generation using single B cell platforms, screening, and lead candidate selection.

The ideal candidate is highly organized, detail-oriented, and comfortable working in a fast-paced, collaborative research environment.

Key Responsibilities

• Perform hands on antibody discovery work flows including cell culture, multi colour flow cytometry to sort and analyse rare immune cell populations.
• Develop, optimize and perform screening cell-based functional assays.
• Characterize antibodies by performing Elisa, SPR, BLI (Octet), Western blot.
• Maintenance of cell lines, freezing, thawing, expansion.
• Perform molecular biology tasks like PCR, cloning, transfection, sequence analysis, RNA/DNA purification methods, gel extraction as needed.
• Ensure all experimental work complies with established protocols and SOP’s.
• Maintain accurate and detailed experimental records and record all experimental data into Electronic Notebook.
• Contribute to troubleshooting, optimization, and continuous improvement of discovery workflows
• Compiling and analysing data by FlowJo, GraphPad Prism, and Excel.
• Conduct analysis and effectively communicate results and present data at internal meetings.
• Collaborate with cross functional teams to align with project goals.
• Committed to fostering an inclusive, collaborative, and innovative research environment.

Please note the roles and responsibilities for the position include but are not limited to the above. 

Knowledge, Experience & Skills

Required

• BS. or M.S. in Molecular Biology, Immunology, Bioengineering, Biochemistry, or related field with 5+> years of experience working in a lab setting (industry experience preferred).
• Experience with antibody discovery platforms including single B cell, hybridoma, or display technologies.
• Proficiency in mammalian cell culture, in vitro assay development and flow cytometry.
• Strong organizational skills, attention to detail and ability to work independently and collaboratively.
• The ability to be a team player and collaborate with colleagues is critical. 

Preferred

• Strong understanding of B cell biology.
• Experience working with antibody sequences, including CDR identification and diversity analysis
• Hands-on experience with multi-color flow cytometry including panel design, staining, compensation, and data analysis/interpretation
• Hands on experience with BLI or SPR.
• Assay development and characterising antibodies using cell-based assays and flow cytometry.
• Comfortable working with high-throughput screening tools or automation.
• Experience with cell engineering technologies, such as transfection, electroporation, lentiviral transduction, and CRISPR.
• Experience with high-throughput antibody expression & purification.
• Experience with cytotoxicity assays using T cell engagers
• Innovative, detail-oriented, and quality-driven with a proactive mindset.
• Exceptional communication and interpersonal skills; able to translate complex data for diverse audiences.
• Highly motivated self-starter with scientific curiosity and a roll-up-your-sleeves attitude.
• Flexible and eager to learn new methods and optimize workflows.

Benefits

We care deeply about the wellbeing of our employees and their families. Our comprehensive benefits include:

• Medical, dental, and vision insurance for employees and dependents
• Flexible Spending Account (FSA)
• Short‑Term Disability (STD), Long‑Term Disability (LTD), Basic Life & AD&D, and Supplemental Life insurance
• 401(k) plan
• 120 hours of Paid Time Off + 5 sick days per year
• 11 public holidays
• Annual bonus program
• Employee referral bonus program
• New hire stock options

Equal Opportunities Statement

OBT is an equal opportunity employer. We welcome applicants of all backgrounds and do not discriminate on the basis of race, colour, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, or veteran status. All qualified applicants will receive fair consideration for employment.

Why Join Us

At OBT, we foster a culture grounded in innovation, scientific excellence, and collaboration. Colleagues describe our environment as friendly, supportive, and hard‑working, where people trust one another and share a commitment to making meaningful impact.

We value diverse perspectives and believe our strength comes from working together with curiosity, respect, and a shared purpose.