The Senior Research Associate will develop and validate NGS assays, design experiments, perform nucleic acid extraction, and communicate findings within a team.
About Us
DELFI Diagnostics, Inc. (DELFI Diagnostics) is developing next-generation, blood-based tests that are reliable, accessible, and deliver a new way to help detect cancer. Employing advanced machine-learning methods to whole-genome sequencing data, the DELFI ("DNA EvaLuation of Fragments for early Interception") platform is built to address the highest-burden health challenges. DELFI Diagnostics prioritizes solutions that have the potential to save lives on a global scale, including for historically underserved populations. DELFI Diagnostics’ platform relies on fragmentomics – the discovery that cancer cells are more chaotic than normal cells and, when they die, leave behind tell-tale patterns and characteristics of cell-free DNA (cfDNA) fragments. FirstLook Lung, for individuals eligible for lung cancer screening, is DELFI Diagnostics’ first laboratory-developed screening test and can be part of routine blood work. FirstLook Lung uses millions of data points to reliably identify individuals who may have cancer detected through low-dose CT, including early-stage disease with a negative predictive value of 99.8 percent. This test has not been cleared or approved by the FDA.
In our passionate pursuit to radically improve health outcomes, we serve humanity when we:
Lead with Science, Anchor in Pragmatism: We pioneer life-changing science by ensuring quality, transparency, and rigor at all times. We explore thoughtfully, experiment smartly, and deliver impact with conviction.
Build With & For All: We embrace diverse backgrounds to innovate and achieve together. We are not just building a product - we aim to disrupt the path of cancer for all - no matter geography or socioeconomic class
Put We over I: We are a home for high-performing people. Through teamwork, we build collective intelligence. Each of us wins when those we serve and those who serve with us--win. We show up with empathy, humility, and integrity at every step of the journey.
About the Role
Join our innovative team dedicated to reducing cancer deaths through cutting-edge liquid biopsy diagnostics. As Sr. Research Associate, you will play a critical role in developing and validating next-generation sequencing assays from concept through commercial launch, working within a collaborative environment of scientists, engineers, and bioinformaticians. You will contribute to product development, verification, and validation activities for NGS-based laboratory tests for early cancer detection. The ideal candidates would have experience working under Good Laboratory Practice (GLP) in a CAP/CLIA/FDA-regulated environment.
What you’ll do
- Contribute to the success of a cohesive, innovative, motivated team that is dedicated to reducing cancer deaths through the following activities:
- Design, execute, and troubleshoot moderate to complex laboratory experiments utilizing molecular biology techniques for Next-Generation Sequencing (NGS).
- Perform end-to-end experimental workflows, including nucleic acid extraction, library preparation, and sequencing, while preparing samples and executing experiments with meticulous attention to detail and adherence to high-quality standards.
- Develop robust assay workflows by performing guard banding studies and verifying product requirements with analytical characterization studies.
- Communicate findings effectively with multidisciplinary teams, including biologists, bioinformaticians, statisticians, automation engineers, and quality control scientists, and present at scientific meetings.
- Contribute to advancing assays through design control processes to meet product requirements and regulatory standards by maintaining comprehensive documentation.
What you’ll have accomplished 6 months from now
- Identified critical quality assay parameters and developed assay specifications to establish a robust assay workflow for DELFI’s lung cancer screening test.
- Become an expert operator of DELFI’s NGS laboratory process
- Proven track record of organization and cross-functional communication for study preparation and execution
What you’ll bring to DELFI
- Required qualifications:
- BS with 3-4 years of experience, or MS with 2-3 years relevant field (e.g., biomedical engineering, molecular biology, genetics, or genomics) in assay development for the life science industry
- Proficient in high-throughput manual laboratory techniques, including precision pipetting for large-scale sample processing
- Proven track record in laboratory method optimization with specialized expertise in addressing technical challenges specific to nucleic acid extraction and library preparation for NGS.
- Strong analytical skills with demonstrated ability to independently design experiments and interpret results using sound scientific reasoning
- Excellent technical writing capabilities for developing experimental protocols, standard operating procedures, and comprehensive development reports
- Superior organizational and project management abilities, including meticulous documentation practices, strategic planning, and effective time management with keen attention to detail
- Hands-on experience with automated liquid handling systems for assay development and execution
- Advanced data analysis skills using Excel and statistical software packages; programming experience in Python, R or similar languages is highly valued
- Direct experience in a regulated environment (CLIA, CAP, NYS, FDA, GXP, etc.)
Preferred qualifications:
An equal opportunity employerWe are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Top Skills
Excel
Molecular Biology
Next-Generation Sequencing
Python
R
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