Senior Scientist, Biologics Discovery, Discovery Biotherapeutics

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Position Summary

The Biologics Discovery organization at Bristol Myers Squibb advances next-generation biotherapeutics through innovative experimental platforms and data-enabled discovery. We integrate immune-based discovery, display technologies, and computational analysis to support high-quality decision-making across early research programs.

We are seeking a Senior Scientist to join our team in Brisbane, CA. This role is a primarily lab‑based scientific position that will contribute directly to biologics discovery by driving immune‑based antibody discovery using advanced single‑cell technologies, while also enabling expansion into cyclic‑peptide discovery via phage display. The position requires strong experimental ownership, coupled with the ability to apply data-driven and computational approaches in close collaboration with computational biology and machine learning partners.

The role offers an opportunity to make a meaningful scientific impact by helping evolve discovery platforms that integrate experimental execution with modern analytical and computational insights.
Key Responsibilities

• Design and execute immune‑based antibody discovery workflows, including immunization schemas design (mRNA and protein), immune cell processing, and application of flow cytometry‑based techniques for immune cell analysis, enrichment, and validation.
• Lead single‑cell antibody discovery efforts (e.g., 10x Genomics), including sample preparation, library generation, and data interpretation.
• Apply understanding of antibody sequence, structure, and developability, with preference for experience using PyMOL, AlphaFold, MOE or related tools for antibody structure prediction and visualization, to guide hit selection and progression.
• Design and execute phage display campaigns to support cyclic‑peptide discovery, including protein‑ and cell‑based panning strategies, and progress cyclic‑peptide hits from phage selections into downstream characterization.
• Analyze and integrate large, complex, and high‑dimensional datasets generated across antibody and cyclic‑peptide discovery workflows.
• Apply data‑driven and computational approaches (e.g., sequence and enrichment analysis; visualization tools such as Spotfire; scripting or statistical tools such as R or Python as a plus) to inform experimental design and hit triage.
• Work closely with computational biology, machine learning, and generative discovery colleagues, with preferred experience contributing to closed‑loop discovery systems that iteratively connect data generation, analysis, and experimental decision‑making.
• Maintain high‑quality experimental documentation and contribute to data‑driven discovery discussions.

Basic Qualifications

• PhD in Immunology, Molecular Biology, Biochemistry, Structural Biology, Bioengineering, or a related scientific discipline with 2+ years of industry experience; or an MS with 5+ years of industry experience; or BS with 7+ years of industry experience.

Preferred Qualifications

• Hands‑on experience in therapeutic antibody discovery, including immune‑based workflows.
• Proficiency in phage display–based discovery, including biopanning, selection, and NGS, preferably using cyclic-peptide libraries; antibody or mRNA phage library experience will also be considered.
• Demonstrated ability to independently design, execute, and interpret experiments under general scientific direction.
• Strong background in molecular biology, flow cytometry, and assay‑based screening.
• Experience analyzing and integrating complex experimental datasets to inform scientific decision‑making.
• In‑depth understanding of antibody sequence analysis, structure–function relationships, and developability assessment is strongly preferred, including experience with PyMOL, AlphaFold, MOE, or related tools.
• Experience applying data visualization and analytical tools (e.g., Spotfire, R, Python, Geneious).
• Familiarity with bioinformatics pipelines and associated concepts used to analyze NGS data.
• Experience working in integrated or high‑throughput discovery environments.
• Prior experience collaborating with machine learning or generative discovery teams, preferably in closed‑loop or iterative discovery systems.
• Strong interpersonal skills and ability to work independently while influencing cross-functional discovery biotherapeutics, biology, automation, and engineering teams.
• Excellent written and verbal communication skills.

#LI-Onsite

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. 
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.
 

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical, pharmacy, dental, and vision care.

• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).

• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

​Work-life benefits include:

Paid Time Off

• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)

• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at [email protected]. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley.