Senior Scientist I, Protein Biochemistry/Enzymology

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are looking for a highly motivated and driven biochemist/enzymologist to join the Discovery Biology team at Revolution Medicines. The ideal candidate will have a deep knowledge of enzyme kinetics, excitement about investigating detailed biochemical mechanisms, and the ability to apply this knowledge to practical, data-driven decisions. The scientist in this position will:

• Design, develop, and apply biochemical assays to functionally characterize proteins, understand their role in oncology, and enable hit finding and validation efforts.

• Perform kinetic studies to support a deep understanding of small molecules with complex mechanisms of action, including covalent and non-covalent molecular glue inhibitors and activators.

• Contribute to early discovery efforts to validate novel oncology targets and therapeutic modalities.

• Support cross-functional teams to generate novel insights and drive drug discovery and development.

• Effectively communicate findings to diverse audiences through presentations, reports, and publications.

Required Skills, Experience and Education:

• Ph.D. in Biochemistry, Enzymology, Chemical Biology, or a related field with 5-8 years of experience, preferably in an industrial setting.

• Thorough understanding of enzyme kinetics and the ability to design, analyze, and interpret experimental results.

• Hands-on experience handling recombinant proteins and analyzing activity through experimental assays (fluorescence, absorbance, luminescence, FRET, mass spectrometry, etc.).

• Rigorous and detail-oriented approach to data analysis and interpretation.

• Knowledge of protein structure-function interpretation and proficiency with software to visualize protein structures.

• Strong analytical and problem-solving skills with the ability to work independently.

• Excellent written and verbal communication skills, including the ability to communicate complex concepts to a variety of audiences.

Preferred Skills:

• Experience in target ID and hit ID stage programs in biotech.

• Proficient with software to model multi-step enzyme reactions (DynaFit, SimBiology, PySB, etc.).

• Familiarity with modern laboratory automation, data systems, and analytics and ability to design experiments to take advantage of these systems. #LI-Hybrid  #LI-LN1