Sr. Software Engineer, Cloud Infrastructure

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California.

Summary:

We are seeking a highly skilled Senior Cloud Infrastructure Engineer to architect, implement, and support cloud-first infrastructure platforms across AWS, Azure, and hybrid environments. This role will be responsible for designing scalable, secure, and highly available cloud infrastructure, managing containerized platforms, automating infrastructure deployments, and supporting critical enterprise and laboratory systems.

The ideal candidate has deep expertise in cloud technologies, Kubernetes, Docker, Infrastructure as Code (IaC), DevOps practices, and cloud security. This individual will work closely with software engineering, bioinformatics, security, laboratory operations, and compliance teams to ensure reliable and compliant infrastructure services supporting business-critical applications.

Onsite: Monday, Tuesday, and Thursday 

Responsibilities:

• Design, deploy, and manage enterprise cloud infrastructure primarily within AWS and/or Azure environments.
• Architect highly available, scalable, secure, and cost-effective cloud solutions.
• Implement cloud networking, identity management, storage, compute, monitoring, and security services.
• Support integration between cloud and on-premises infrastructure environments.
• Manage hybrid networking, VPNs, Direct Connect, ExpressRoute, and secure connectivity solutions.
• Support virtualization platforms and legacy infrastructure during cloud transformation initiatives.
• Design, deploy, and manage Kubernetes clusters in cloud and hybrid environments.
• Administer container orchestration platforms including Amazon EKS, Azure AKS, or self-managed Kubernetes environments.
• Build and maintain containerized application platforms using Docker.
• Automate infrastructure provisioning, configuration management, and deployment processes.
• Support and optimize CI/CD pipelines using GitHub Actions, GitLab CI, Azure DevOps, Jenkins, or similar platforms.
• Implement automated monitoring, alerting, scaling, backup, and recovery solutions.
• Partner with Security and Compliance teams to support HIPAA/CLIA/CAP/FDA requirements, where applicable.
• Ensure secure management of Protected Health Information (PHI) and sensitive business data.
• Partner with software engineering teams to optimize cloud-native application architectures.

Required Qualifications:

• Bachelor's degree in Computer Science, Information Technology, Engineering, or related field.
• 7+ years of infrastructure engineering experience.
• 5+ years of hands-on cloud engineering experience in AWS, Azure, or GCP.
• 3+ years of Kubernetes administration and container platform management experience.
• Strong experience with Docker and containerized application deployment.
• Experience implementing Infrastructure as Code using Terraform or equivalent tools.
• Experience with Linux systems administration and cloud networking.
• Strong scripting and automation skills using Python, PowerShell, Bash, or similar languages.
• Experience supporting production-critical environments with high availability requirements.

Technical Skills:

• AWS (EC2, EKS, RDS, S3, IAM, VPC, Route53, CloudWatch, Lambda)
• Azure (AKS, Virtual Networks, Azure AD, Storage, Monitor, Key Vault)
• Multi-cloud and hybrid-cloud architectures
• Kubernetes, Docker, Helm, EKS, Terraform, Ansible and other adjacent cloud services
• Monitoring services like Splunk, Datadog or other cloud-native monitoring tools

Key Competencies:

• Cloud Architecture & Engineering
• Kubernetes Administration
• Docker & Container Platforms
• Infrastructure Automation
• DevOps & CI/CD
• Cloud Security & Compliance
• Site Reliability Engineering (SRE)
• Disaster Recovery & Business Continuity
• Technical Leadership
• Problem Solving & Incident Management

Success Metrics:

• Cloud platform availability and reliability.
• Kubernetes cluster health and operational efficiency.
• Infrastructure automation coverage and deployment success rates.
• Compliance with HIPAA, CLIA, CAP, and security requirements.
• Cloud cost optimization and resource utilization.
• Incident response and recovery performance.
• Successful delivery of cloud modernization initiatives.
• Security and audit readiness.

The hiring range for this position is $150,000 to $180,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

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