Top Principal Software Engineer Jobs in San Francisco, CA

Responsible for architecting and modernizing Salesforce's data ecosystem, optimizing performance, and leading design for AI and knowledge graph integration.

The Principal Software Engineer will design and build software systems for AI platforms, mentor engineers, and guide technical vision across teams.

As a Principal Software Engineer, you'll architect scalable backend systems for mobile applications, mentor teams, and influence tech strategy to support mobile-first growth.

The Principal Software Engineer leads technical standards and product design in a collaborative hybrid environment, focusing on complex software solutions, cloud services, and mentoring teams.

You will lead the development of key platform components at Onos Health, focusing on healthcare data integrations, architectural decisions, and team growth while collaborating closely with machine learning engineers.

Lead the development of core data platform capabilities at Benchling. Design data architecture, mentor engineers, and implement scalable data solutions across biotech companies.

The Principal Backend Software Engineer leads complex architecture projects, unblocks development challenges, and mentors junior engineers while ensuring high-quality code standards.

The Principal Software Engineer will lead application development for M&A and Operations, focusing on backend architecture, coding quality, and testing methodologies, while managing junior engineers and enhancing system integration.

Lead the design and operation of the Gradient AI platform, focusing on scalability, performance, and innovation in agent development. Mentor engineers and collaborate across teams to deliver strategic technical roadmaps and enhance operational excellence.

As a Principal Software Engineer, you'll lead architectural strategies, mentor engineers, prototype services, and ensure alignment with business goals in a remote environment.

The Principal Full Stack Software Engineer will lead technical direction, collaborate with teams, mentor engineers, and ensure high-quality code for SaaS products.

The Principal Software Engineer will define technical roadmaps, guide system architecture, mentor leaders, and drive product direction in Capital Supply operations.

Lead mobile software development as a Principal Mobile Software Engineer, driving technical strategy, building systems in React Native, and mentoring engineers to enhance user experience and scalability.

Lead the design and development of large-scale perception systems for an autonomous driving platform, focusing on optimizing resource sharing and performance.

As an iOS Software Engineer, improve the iOS app infrastructure, streamline processes, and maintain app releases while mentoring junior engineers.

The Principal Engineer will lead the design and delivery of AI solutions, mentor engineers, and align global AI architectures, focusing on applied AI and agentic AI platforms.

Lead the development of software solutions for Early Clinical Development, mentor engineers, and drive technical strategies for clinical trial data and AI/ML integration.

The Principal Software Engineer will lead backend architecture, focusing on infrastructure, security, and developer experience. Responsibilities include designing scalable systems, mentoring engineers, and collaborating across teams to optimize productivity while ensuring security compliance.

Design and scale PaaS and Data Infrastructure for SaaS products. Lead technical execution of distributed systems and automation pipelines while mentoring engineers and enforcing standards for reliability and performance.

The Principal Software Engineer, Applied AI will lead AI integration in cloud-native applications, mentor engineers, and ensure robust, scalable solutions. Responsibilities include full stack feature development, backend service design, and creating intuitive AI-driven user workflows.

Lead design and implementation of Generative AI features, mentor engineers, ensure performance and reliability, collaborate with product teams, and maintain high quality standards.

We are seeking a Senior/Staff/Principal Software Engineer with extensive experience in software development, expertise in distributed systems, and strong leadership skills. The role involves building and optimizing a large-scale AI product for financial advisors. Responsibilities include system architecture, technical documentation, and team collaboration. Candidates should be proficient in Elixir and familiar with various tech stacks, cloud services, and best coding practices.

Lead technical projects in building data-intensive capabilities for Elasticsearch's new compute engine, especially focusing on ES|QL. Collaborate with product teams and mentor engineers, driving an innovative roadmap and delivering efficient software solutions.

Lead the architecture and design of large-scale systems, optimize performance, influence engineering practices, and implement AI solutions across software development lifecycles.

The Principal Software Engineer will define technical direction, design scalable systems for identity verification, and mentor engineers at Nametag.