Top Principal Software Engineer Jobs in San Francisco, CA

Lead critical infrastructure initiatives at Discord, shaping technical vision, mentoring engineers, and designing reliable systems for millions of users.

The Principal Software Engineer will design and develop secure software solutions in the cloud, lead technical direction, improve engineering processes, and collaborate on applications and documentation.

You will lead the development of key platform components at Onos Health, focusing on healthcare data integrations, architectural decisions, and team growth while collaborating closely with machine learning engineers.

As a Principal Software Engineer, you will lead the development and architecture of Upstart's Core GenAI Platform, ensuring technical excellence and cross-team collaboration while mentoring junior engineers and influencing business strategy.

Lead the architectural design and development of a new consumer credit product, focusing on backend systems, distributed services, and integrating AI tools. Mentor team members and influence product direction through engineering insights.

As a Principal Software Engineer, you'll lead architectural strategies, mentor engineers, prototype services, and ensure alignment with business goals in a remote environment.

Lead the design and development of large-scale perception systems for an autonomous driving platform, focusing on optimizing resource sharing and performance.

The Principal Software Engineer will define technical roadmaps, guide system architecture, mentor leaders, and drive product direction in Capital Supply operations.

As a Principal Full Stack Software Engineer, you will lead the technical direction, mentor engineers, and influence product strategy within a remote setup, primarily utilizing Java, Kotlin, and AWS.

Lead the development of software solutions for Early Clinical Development, mentor engineers, and drive technical strategies for clinical trial data and AI/ML integration.

Lead the development of healthcare software, manage a team of engineers, and collaborate on architecture and product requirements while maintaining high standards of quality and security.

Lead a software engineering team to develop healthcare software, mentoring members, collaborating closely with product and design teams, and ensuring high-quality delivery.

As a Software Engineer, you will enhance computational and data ecosystems, develop scalable systems, and integrate AI to accelerate drug discovery.

The Principal Software Engineer leads technical standards and product design in a collaborative hybrid environment, focusing on complex software solutions, cloud services, and mentoring teams.

Responsible for architecting and modernizing Salesforce's data ecosystem, optimizing performance, and leading design for AI and knowledge graph integration.

As a Principal Software Engineer, you'll enhance parsing capabilities for ECAD files, contribute to system architecture, and mentor engineers.

Lead the development and maintenance of high-performance cross-platform desktop and mobile applications for HiFi audio. Drive technical direction, mentor team members, and innovate audio streaming solutions while ensuring product scalability and performance.

As a Principal Software Engineer, you will architect full-stack solutions for the Cars.com marketplace, guiding teams and ensuring technical excellence to improve user experiences in car buying and selling.

As a Principal Software Engineer, lead end-to-end projects, mentor engineers, and contribute to system architecture and full-stack development, enhancing the platform's efficiency and maintainability.

As a Principal Software Engineer, you'll drive technical architecture, mentor teams, and lead software development projects while contributing to code and best practices.

The Staff/Principal Software Engineer will lead the development of full-text search capabilities, focusing on search infrastructure, collaboration, and innovative solutions in AI applications at Pinecone.

As the Area Technical Lead, you will architect and improve the ML data strategy for autonomous driving, enhancing the data-driven self-improvement process for the Waymo Driver.

The Principal Software Engineer, Payments, leads design and architecture of Turo's payment systems, mentors engineers, and collaborates with cross-functional teams to ensure operational excellence.

The role involves developing sensor-fusion models for autonomous driving, optimizing model deployment, and leading technical teams in machine learning engineering.

Seeking a Principal Software Engineer to build developer products for LLM applications, ensuring high-quality tools and APIs while leading engineering practices and collaborating across teams.