Top Principal Software Engineer Jobs in San Francisco, CA

Lead a small AI-First engineering team to design, orchestrate, and verify agent-driven development workflows. Define agent toolchains, context engineering, and governance; architect full-stack applications; enforce multi-layer verification and automated QA; mentor engineers; optimize token/cost; and continuously improve AI-assisted SDLC practices and standards.

The role involves developing and maintaining backend services, collaborating with teams, optimizing code, and ensuring compliance in a rapidly evolving tech environment.

The Principal Software Engineer, Cloud will lead the Cloud Platform team to define technical strategy and architectural direction, ensuring robust cloud systems for robotics and AI applications.

Lead remote engineering teams to design, architect, and deliver scalable, high-availability education technology platforms focused on content systems, workflows, and GenAI. Drive product and technical strategy, collaborate with product/design, implement cloud-native architectures, adopt agile practices, measure performance through data and testing, and continuously improve user engagement and platform reliability.

Lead architecture and development of high-performance, scalable backend systems for Yahoo Mail using Java and C++. Set technical strategy, establish architectural standards, validate AI-generated code, mentor senior engineers, collaborate cross-functionally, and ensure reliability through automated logging, telemetry, and debugging workflows.

Design and build high-performance UI and APIs, manage database architecture, optimize systems for reliability and performance, and collaborate cross-functionally in a scientific context.

You will architect and build cloud infrastructure, optimize systems, evolve CI/CD pipelines, manage infrastructure, and mentor engineers, focusing on AI-driven solutions.

Lead architecture and technical direction for Athena, a production-grade distributed system that validates, deduplicates, and routes enterprise vulnerability data. Drive transition from prototypes to maintainable systems with observability, SLOs, incident handling, and operational rigor. Partner across teams on domain ownership, hire and raise engineering standards, and design pipelines that extract clean signals from unstructured vulnerability reports.

As a Senior Software Engineer, you will architect and implement systems for AI solutions, lead engineering efforts, and ensure secure code development. You'll collaborate with teams and shape product direction while managing proof-of-concept projects and maintaining information security.

Design and build autonomous accounting agents, implement a custom accounting ledger, integrate financial data providers, and ship daily features using TypeScript/Node/Svelte. Work rapidly in an early-stage startup, make product decisions, and engage in customer problem discovery.

Lead design and implementation of advanced systems features for Postgres, focusing on performance optimization and scalability. Mentor engineers and drive architectural direction for large-scale database systems.

Lead AI adoption initiatives and cultural transformation in engineering at Yahoo Mail, enhancing developer productivity through AI tools and practices.

Lead architecture and technical strategy across an infrastructure platform ecosystem. Drive hands-on architectural improvements to graph engine and backend services, reduce technical debt, establish standards, champion AI-first engineering practices, run architecture/code reviews and mentorship, and collaborate with product and leadership to ensure scalable, extensible systems.

The Principal Software Engineer will drive the technical roadmap for Panthey's hosting platform, architect core services, and provide technical leadership and mentoring to engineers. They will work on distributed systems, container orchestration, and AI-native engineering practices, ensuring platform reliability and performance.

Senior backend engineer role owning architecture, implementation, and reliability across CloudZero products. Lead design decisions, mentor engineers, improve performance and scalability, collaborate with product and customers, and deliver production-grade data pipelines and cloud systems.

Lead the development of healthcare software, manage a team of engineers, and collaborate on architecture and product requirements while maintaining high standards of quality and security.

Lead a software engineering team to develop healthcare software, mentoring members, collaborating closely with product and design teams, and ensuring high-quality delivery.

Lead technical aspects of an engineering team, design and revamp systems, improve efficiency, mentor engineers, and contribute to product strategy.

As a Principal Software Engineer, you will architect WEX's Data-as-a-Service platform, set standards, guide strategy, and mentor teams while driving innovation with modern technologies.

Lead technical direction and architecture for teams at Salesforce, driving AI-native data integration solutions and overseeing quality delivery of backend engineering.

The Principal Software Engineer - Backend drives technology direction for backend systems, ensures service reliability, and mentors teams while shaping architecture and standards across Autodesk's systems.

As a Senior Principal Software Engineer, you'll develop a unified data platform, architect infrastructure, implement APIs, and mentor teams, focusing on data processing and reliability.

Lead design, architecture, and hands-on implementation of scalable healthcare SaaS systems. Drive interoperability (HL7, FHIR, EDI), mentor engineers, liaise with stakeholders, manage technical risk, and ensure quality, performance, security, and innovation.

Founding engineer responsible for architecting and building core product systems, writing scalable Python backend code, designing and maintaining AI/ML infrastructure, instituting best development practices (testing, CI/CD), collaborating on product roadmap, and mentoring future engineers.

Design, build, and improve Elasticsearch distributed-systems components for scalable, concurrent, and consistent indexing. Maintain cluster coordination for performance and resilience, push system scale limits, investigate performance and concurrency issues, support operations/support engineers, and lead projects involving multiple engineers from design through delivery.