Scientist II – Oligonuleotide Synthesis

Our client, a world leader in biotechnology and gene therapy, is looking for an “Scientist II – Oligonuleotide Synthesis” based in South San Francisco, CA.

Job Duration: Long Term Contract (Possibility Of Extension)

Pay Rate : $53/hr on W2

Company Benefits: Medical, Dental, Vision, Paid Sick leave, 401K

We are seeking a Scientist II to join the Nucleic Acid Design and Discovery (NADD) team. This role focuses on oligonucleotide therapeutics discovery, supporting RNAi-based research through synthesis, characterization, and collaboration across therapeutic areas.

Key Responsibilities

• Design and execute oligonucleotide synthesis and purification workflows.
  
• Perform HPLC and mass spectrometry analysis for characterization and impurity profiling.
  
• Support RNAi and nucleic acid therapeutic discovery across neuroscience, immunology, and oncology programs.
  
• Develop and scale up synthesis of lead oligonucleotide candidates for preclinical studies.
  
• Collaborate with cross-functional teams to integrate chemistry and biology data.
  
• Maintain and troubleshoot lab equipment (e.g., oligo synthesizers, HPLC systems).
  
• Conduct literature reviews and contribute to experimental design and strategy.
  

Qualifications:

• BS/MS in Organic Chemistry or related field.
  
• Hands-on experience with oligonucleotide synthesis, purification, and characterization.
  
• Experience with automated oligo synthesizers, HPLC, and mass spectrometry.
  
• Understanding of RNAi, nucleic acid therapeutics, and modification chemistries preferred.
  
• Industry experience in biotech/pharma R&D is a plus.
  

If interested, please send us your updated resume at

[email protected]/[email protected]