Alector
Senior Director, CMC Technical Operations, siRNA Therapeutics
Similar Jobs
Artificial Intelligence • Cloud • Security • Software • Cybersecurity
Lead and scale strategic ISV go-to-market partnerships globally by aligning with Product, developing and executing GTM plans, driving joint revenue opportunities, enabling field and partner sales, creating marketplace listings, and measuring partnership performance to optimize impact.
Top Skills:
AICloud MarketplacesCloud TechnologiesDatadogSecurity
.png)
Consumer Web • eCommerce • Machine Learning • Software • Sports • Analytics
Design, build, and operate scalable AWS-based backend services and APIs for the Collectors Vault. Own architecture and delivery, improve performance and reliability, mentor engineers, and leverage modern AI tools to accelerate development and engineering velocity.
Top Skills:
APIsAWSC#Claude Code CliCodexEvent-Driven ArchitecturesJavaServerless
Consumer Web • eCommerce • Machine Learning • Software • Sports • Analytics
Lead backend and full-stack work on the Payments team, building multi-gateway integrations (Stripe, PayPal), payment APIs, and customer payment UIs. Ensure secure, compliant (PCI-DSS) payment flows, reliability, observability, and scalability across AWS/Kubernetes microservices. Partner cross-functionally to design architecture, implement settlement/reconciliation, and maintain high availability.
Top Skills:
.NetAi-Assisted Development ToolsAWSC#DatadogDynamoDBKafkaKubernetesPaypalPci-DssPostgresReactStripeSvelteTypescript
Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history.
As the Senior Director, CMC Technical Operations, siRNA Therapeutics, you are a senior technical leader advancing siRNA programs from late discovery through clinical development and toward commercialization. You will serve as the CMC technical lead across internal teams and external partners, ensuring robust, scalable, and phase-appropriate manufacturing processes for siRNA drug substance and drug product.
This is an individual contributor role with broad cross-functional influence. You will report to the Vice President of Technical Operations and partner closely with Research, Process Development, Analytical Development, Regulatory, Quality, and CDMOs to deliver high-quality siRNA therapeutics in a dynamic biotech environment.
Key Goals and Accountabilities:
- Lead CMC strategy for one or more siRNA programs, aligning manufacturing plans with development timelines and corporate objectives to enable seamless clinical progression and long-term commercialization readiness
- Drive development, optimization, scale-up, and tech transfer of oligonucleotide drug substance processes—including solid-phase synthesis, deprotection, purification (e.g., HPLC, TFF), and GMP manufacturing—to ensure robust and reliable supply
- Advance drug product development, including formulation and lipid nanoparticle (LNP) encapsulation, delivering phase-appropriate control strategies, comparability plans, and risk assessments that support regulatory success
- Provide strong technical oversight of CDMOs, leading manufacturing campaigns, managing deviations and investigations, and ensuring quality and regulatory alignment across global partners
- Integrate innovative technologies—including AI-enabled data analysis and digital process tools—into CMC operations to accelerate development timelines, enhance decision-making, and conserve valuable resources
Required Qualifications:
- BS, MS, or PhD in Chemical Engineering, Biochemistry, Pharmaceutical Sciences, or a related scientific discipline
- 12+ years experience in CMC development within biotechnology, with direct experience in siRNA, oligonucleotide, or other RNA-based therapeutics
- Demonstrated expertise in oligonucleotide drug substance manufacturing, including scale-up and GMP tech transfer
- Experience overseeing CDMO partnerships and external manufacturing activities in a clinical-stage setting
- Strong knowledge of global regulatory expectations for CMC documentation and phase-appropriate development strategies, with experience supporting IND and early clinical programs
- Excellent technical writing and communication skills, with the ability to influence cross-functional stakeholders
- Active user of large language models (LLMs) with a strong interest in evolving AI technologies and their application to CMC and technical operations
Preferred Qualifications:
- Experience contributing to regulatory submissions (IND/CTA/BLA), including authoring and reviewing CMC sections and responding to agency queries
- Experience supporting nucleic acid drug product development, including LNP-based delivery systems
- Demonstrated ability to operate effectively as a senior individual contributor in a fast-paced, matrixed biotech environment
#LI-DM1
At Alector, our vision is bold, people are our priority, and our values are at the core of everything we do. Our dynamic and flexible environment encourages our teams to experiment, take ownership of decisions, and question convention to solve complex problems. We value shared wins, perseverance, and a growth mindset, which drives us forward, together.
Among the things you'll discover at Alector from your very first day are our committed and driven colleagues, a bold company vision, and new, modern offices designed to inspire innovation and collaboration in South San Francisco, right at the heart of Biotech Bay. Our benefits are thoughtfully designed around Alectorians and their loved ones and include flexible hybrid work options, competitive compensation, and comprehensive and unique benefits that enhance your health and well-being. Come join us!
We believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other’s assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation.
Review our Privacy Policy
Alector San Francisco, California, USA Office
131 Oyster Point Blvd, San Francisco, CA, United States, 94080
What you need to know about the San Francisco Tech Scene
San Francisco and the surrounding Bay Area attracts more startup funding than any other region in the world. Home to Stanford University and UC Berkeley, leading VC firms and several of the world’s most valuable companies, the Bay Area is the place to go for anyone looking to make it big in the tech industry. That said, San Francisco has a lot to offer beyond technology thanks to a thriving art and music scene, excellent food and a short drive to several of the country’s most beautiful recreational areas.
Key Facts About San Francisco Tech
- Number of Tech Workers: 365,500; 13.9% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Google, Apple, Salesforce, Meta
- Key Industries: Artificial intelligence, cloud computing, fintech, consumer technology, software
- Funding Landscape: $50.5 billion in venture capital funding in 2024 (Pitchbook)
- Notable Investors: Sequoia Capital, Andreessen Horowitz, Bessemer Venture Partners, Greylock Partners, Khosla Ventures, Kleiner Perkins
- Research Centers and Universities: Stanford University; University of California, Berkeley; University of San Francisco; Santa Clara University; Ames Research Center; Center for AI Safety; California Institute for Regenerative Medicine
