Sr. Director, Commercial Supply Chain

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:

Reporting to the VP, Global Manufacturing & Supply Chain, the Sr. Director of Commercial Supply Chain will provide strategic and operational leadership for end-to-end supply chain planning across late phase clinical and commercial programs. This role is responsible for ensuring uninterrupted supply of small molecule drug substance, drug product and packaging & labeling through robust planning, inventory management, and cross-functional coordination.

The successful candidate will lead Sales & Operations Planning (S&OP) and Clinical Operations Planning (C&OP), support launch readiness, and establish scalable systems and processes to support a growing global supply network ensuring 100% supply reliability to patients.

Job Responsibilities:

Strategic Supply Chain Leadership & Planning

• Define and execute global supply chain strategies to support clinical development, commercialization, and lifecycle management.
• Lead end-to-end Sales & Operations Planning (S&OP) and Clinical Operations Planning (C&OP) processes.
• Ensure alignment of demand forecasts with manufacturing and supply capabilities.
• Provide strategic input into supply chain network design, long-term capacity planning, and budget development.

Demand Planning, Forecasting & Supply Balancing

• Collaborate with Clinical Operations, Commercial, and CMC teams to develop accurate demand forecasts.
• Lead demand and supply balancing activities across all supply chain echelons.
• Establish processes to continuously refine forecasts and improve planning accuracy.
• Ensure alignment of demand signals with production and procurement plans.

Inventory Management & Optimization

• Define and manage inventory strategies across the global network.
• Establish operational and strategic safety stock levels to mitigate supply risk.
• Monitor inventory performance, including turns, expiry risk, and working capital.
• Drive optimization of inventory levels to balance service, cost, and risk.

Launch Planning & Commercial Readiness

• Lead supply chain planning for product launches, including scenario planning and risk mitigation.
• Ensure readiness of supply chain systems, processes, and inventory to support successful launches.
• Partner with cross-functional teams to support regulatory milestones and market entry.

Network Planning & Risk Management

• Lead long-range supply chain network planning to support growth and commercialization.
• Identify and mitigate supply risks through scenario planning, redundancy strategies, and contingency planning.
• Develop and maintain risk management frameworks across the supply chain.
• Support business continuity planning and supply resilience initiatives.

Systems, Tools & Data Management

• Lead design, selection, and implementation of supply chain planning tools.
• Ensure effective master data management to support planning and execution.
• Support ERP system implementation and integration for new products and supply chains.
• Drive digital transformation and data-driven decision making in supply chain operations.

Logistics, Distribution & Storage

• Oversee storage, shipping, and distribution strategies for clinical and commercial products.
• Ensure compliance with requirements for controlled room temperature (CRT) and cold chain products.
• Coordinate logistics across global CDMOs, depots, and distribution partners.
• Optimize distribution networks to ensure timely and cost-effective delivery.

Cross-Functional Leadership & Execution

• Partner closely with External Manufacturing, Quality, Regulatory, Clinical Operations, and Commercial teams.
• Serve as a key member of the Manufacturing & Supply Chain and Technical Operations teams.
• Drive continuous improvement initiatives across supply chain processes.
• Ensure alignment across stakeholders to support uninterrupted patient supply.

Qualifications:

• B.S. in Supply Chain, Engineering, Chemistry, or related discipline required; MBA preferred.
• 15+ years of experience in supply chain management within the pharmaceutical or biotech industry.
• Deep expertise in small molecule manufacturing and oral solid dose (OSD) products/supply chains.
• Deep expertise in supply chain planning, S&OP/C&OP, and inventory management.
• Proven experience in launch planning and commercialization support.
• Experience with global outsourced supply chains and CDMO networks.
• Strong knowledge of GMP regulations, validation, CPV, and quality systems.
• Experience working with global manufacturing networks and international CDMOs across multiple time zones.
• Expertise in supply chain planning systems and ERP implementations.
• Experience with supply chain integration, production planning, and capacity management.
• Strong knowledge of logistics, distribution, and cold chain requirements.
• Demonstrated experience in risk management and supply chain resilience.
• Excellent leadership, communication, and cross-functional collaboration skills.
• Ability to operate effectively in a fast-paced, matrixed, and virtual organization.
• Strategic thinker with strong execution and decision-making capabilities.
• Proven ability to build high-performing teams and operate in matrix environments.
• Strategic thinker with strong execution capabilities.
• Excellent communication and cross-functional influence.

Travel Required: up to 20-25%, globally

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. For this role, the anticipated base pay range is $248,000-$305,000. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, and ongoing performance-based equity. Structure Therapeutics also offers various benefits offerings, including, but not limited to, medical, dental, and vision insurance, 401k match, unlimited PTO, and a number of paid holidays including winter shutdown.

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