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Tempus AI

Sr Manager, Software Engineering

Sorry, this job was removed at 09:14 a.m. (PST) on Tuesday, Jul 21, 2026
Remote or Hybrid
Hiring Remotely in Illinois, USA
Remote or Hybrid
Hiring Remotely in Illinois, USA

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Lead and grow strategic global accounts with biopharma clients for Tempus Diagnostics and Research services. Develop account strategies, meet revenue goals, build executive and R&D relationships, negotiate complex contracts, coordinate cross-functional teams, and track progress against strategic objectives. Serve as a strategic advisor to advance precision medicine and enable case studies. Travel ~30%.

Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

As a Sr Manager, you will be the primary guardian of data reliability and a mentor to a high-performing engineering squad. You are a "Data Reliability Engineer" who ensures that our complex multi-modal datasets—spanning clinical records, genomics and radiology —are accurate, traceable, and ready for high-stakes applications like machine learning and clinical decision-making.

In this leadership capacity, you will manage a small team of engineers leveraging cutting-edge AI-assisted development tools to accelerate delivery.

What You’ll Do
  • Team Leadership & Mentorship: Lead and manage a small, agile team of software engineers. Conduct code reviews, provide technical guidance, and foster a culture of excellence in data quality and engineering best practices.

  • DBT Testing & Quality Gates: Architect and implement a comprehensive testing suite within DBT. Design and enforce data quality gates in the CI/CD and ETL  pipeline to ensure that only high-integrity data reaches production environments.

  • Deep Data Analysis & Profiling: Perform exhaustive data profiling and deep-dive analyses using SQL and Python to evaluate completeness, identify hidden patterns, and resolve structural inconsistencies.

  • Product Strategy & Planning: Collaborate directly with Product Managers and other Team Leads to develop and prioritize the product backlog. You will be responsible for identifying work estimates and refining complex requirements into actionable technical tasks.

  • Modern Data Stack & Observability: Architect and implement robust observability frameworks using BigQuery, DBT, Elementary, and Grafana to create real-time monitors, alerts, and dashboards that track the health and lineage of our data ecosystem.

  • AI-Driven Development: Champion the use of AI productivity tools—such as Cursor, Claude, and GitHub Copilot—to streamline development, automate testing, and refactor legacy data pipelines efficiently.

  • Statistical Insights & KPIs: Define and report on key Data Quality KPIs (e.g., freshness, volume, and schema changes) using correlation and trend analysis to provide platform-wide transparency.

  • Advanced Data Modeling: Manage an enterprise data model integrating multiple domains (Clinical, NGS, Radiology) across relational and NoSQL technologies.

Why We’re Looking for You
  • Technical Proficiency: You are an expert in the modern data engineering stack, specifically DBT, SQL, and Python.

  • Leadership Experience: You have a proven track record of leading or mentoring a small team of engineers in a fast-paced environment.

  • Observability & AI Savvy: You have hands-on experience with observability tools (e.g., Elementary, Grafana) and are proficient in leveraging AI coding assistants (Cursor, Claude, Copilot) to enhance team velocity.

  • Domain Expertise: You have a strong background in healthcare and next-generation sequencing (NGS) data.

  • Analytical Powerhouse: You use data profiling and correlation analysis to solve complex data integrity problems.

  • Communication: Ability to translate technical data quality gaps into actionable insights for both internal developers and external stakeholders.

Chicago: $150,000 - $210,000

NY/SF: $175,000 - $225,000

The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.

We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. 

Tempus AI Redwood, California, USA Office

Tempus AI Bay Area - Tempus Office Office

Our Redwood City office is located in a waterfront neighborhood at the heart of Silicon Valley, providing convenient access to tech hubs and boasting a thriving business scene. With excellent transport options and a range of dining choices, it's a dynamic hub for professionals and tech enthusiasts.

What you need to know about the San Francisco Tech Scene

San Francisco and the surrounding Bay Area attracts more startup funding than any other region in the world. Home to Stanford University and UC Berkeley, leading VC firms and several of the world’s most valuable companies, the Bay Area is the place to go for anyone looking to make it big in the tech industry. That said, San Francisco has a lot to offer beyond technology thanks to a thriving art and music scene, excellent food and a short drive to several of the country’s most beautiful recreational areas.

Key Facts About San Francisco Tech

  • Number of Tech Workers: 365,500; 13.9% of overall workforce (2024 CompTIA survey)
  • Major Tech Employers: Google, Apple, Salesforce, Meta
  • Key Industries: Artificial intelligence, cloud computing, fintech, consumer technology, software
  • Funding Landscape: $50.5 billion in venture capital funding in 2024 (Pitchbook)
  • Notable Investors: Sequoia Capital, Andreessen Horowitz, Bessemer Venture Partners, Greylock Partners, Khosla Ventures, Kleiner Perkins
  • Research Centers and Universities: Stanford University; University of California, Berkeley; University of San Francisco; Santa Clara University; Ames Research Center; Center for AI Safety; California Institute for Regenerative Medicine

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