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Tempus AI

Structural Biologist III

Posted 14 Days Ago
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Hybrid
Aliso Viejo, CA
120K-170K Annually
Senior level
Hybrid
Aliso Viejo, CA
120K-170K Annually
Senior level
The Structural Biologist III develops structural modeling, molecular dynamics, and clinical variant assessment methods and tools. The role interprets structure-function relationships, supports clinical research, validates algorithms with data science teams, writes production-grade code, maintains technical documentation, and leads structural biology projects and staff. The position requires cross-functional collaboration with biology, bioinformatics, software engineering, statistics, and clinical teams.
The summary above was generated by AI

Compensation:

$120,000 - $170,000

Role Overview

The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions.

Key Responsibilities

  • Provide structural biology support for variant analyses through structure-function relationship interpretation.

  • Develop novel methods, protocols, and tools for structural modeling, molecular dynamics, and clinical variant assessment on internal platforms.

  • Partner with statisticians and data scientists to validate algorithms and data collection workflows.

  • Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams for clinical research projects.

  • Write testable, production-grade code adhering to SDLC standards and code review best practices.

  • Maintain technical documentation, SOPs, and knowledge bases while mentoring junior staff.

  • Direct and lead the structural team through both soft and explicit leadership ensuring timely project completion

  • Support, inform, and educate leadership and stakeholders about project progress and blockers.

Qualifications & Competencies

  • Education: PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent.

  • Experience: Minimum 5 years of R&D experience in computational structural biology or related fields, including at least 2 years of post-doctoral or industrial experience and 2 years management experience.

  • Technical Skills: Fluency/proficiency in scripting/languages (Python, R, Perl, C/C++, Java, SQL) and bioinformatics/modeling software. Strong background in systems biology, molecular dynamics, and experimental techniques (X-ray, Cryo-EM).

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Equal Opportunity Employer

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