The Chief Commercial Officer will lead commercial partnerships, drive revenue growth, design sales systems, and mentor sales teams while engaging Fortune 500 companies.
About the Role
Key ResponsibilitiesCorporate Partnership Development
Sales Strategy & Commercial Infrastructure
Revenue Leadership & Team Enablement
Functional Collaboration
We’re seeking a Chief Commercial Officer to serve as the commercial engine building corporate partnerships at UP.Labs. This is a high-impact, senior-level role focused on generating revenue through new and existing corporate relationships, designing scalable sales systems, and driving commercialization efforts.
As the Chief Commercial Officer, you will own the partner pipeline—from initial outreach through deal close—helping UP.Labs land transformative enterprise collaborations with Fortune 500 companies. You’ll design and execute repeatable commercialization frameworks, leverage AI-driven tools to identify and qualify opportunities, and build the sales infrastructure that fuels UP.Labs’ long-term growth.
This is both a strategic and hands-on role for a seasoned sales leader who thrives in fast-moving, entrepreneurial environments and has a proven track record of building enterprise revenue engines from the ground up.
- Identify, engage, and close new corporate partnerships.
- Build and manage a robust pipeline of enterprise prospects at target industries.
- Develop and deliver compelling pitches, proposals, and partnership structures that align with UP.Labs’ venture creation model.
- Lead negotiations and deal execution, driving strategic partnerships from initial outreach through signed agreement.
- Design and implement the commercialization systems, processes, and playbooks that power corporate partnership growth.
- Develop scalable sales frameworks, pricing strategies, and go-to-market playbooks that can be applied at different industries and partner types.
- Manage CRM and sales platforms, track performance metrics, and establish reporting standards for pipeline visibility and forecasting accuracy.
- Use AI and data-driven insights to optimize lead generation, qualification, and conversion strategies.
- Build and lead a high-performing inside sales function to support partner engagement and outreach.
- Mentor and train junior sales and commercialization team members on enterprise sales tactics, CRM best practices, and partner engagement.
- Collaborate closely with Marketing to refine messaging, positioning, and outbound campaigns that resonate with senior corporate decision-makers.
- Maintain deep understanding of market dynamics, competitive trends, and partner needs to inform revenue strategy.
- Work hand-in-hand with the Head of Special Operations, venture leads, and executive leadership to align commercialization goals with overall studio strategy.
- Represent UP.Labs in senior-level meetings with corporate executives, driving confidence and clarity in our partnership approach.
- Support executive communications, materials preparation, and strategic follow-ups for key enterprise accounts.
You Should Have
- 10+ years of experience in commercial strategy or revenue leadership roles within B2B technology or services organizations.
- Experience selling AI innovation services into enterprise organizations and a strong rolodex.
- Proven success building revenue engines and leading commercialization in high-growth or startup environments.
- Expertise in enterprise sales processes including procurement, compliance, and multi-stakeholder management.
- Demonstrated ability to land and expand complex enterprise partnerships and strategic alliances.
- Proficiency in CRM and modern sales tools (HubSpot, Salesforce, Outreach, Apollo, etc.), with a strong data-driven approach to sales management.
- Entrepreneurial mindset—comfortable operating autonomously, building systems from scratch, and adapting quickly to changing priorities.
- Excellent communication, relationship-building, and negotiation skills with C-suite and enterprise-level stakeholders.
Location: Major Metro preferred
Travel: 10-15+ weeks per year
UP.Labs San Carlos, California, USA Office
655 Skyway Rd., San Carlos, CA, United States, 94070
Similar Jobs
Artificial Intelligence • Blockchain • Fintech • Financial Services • Cryptocurrency • NFT • Web3
Build and extend smart contracts and backend services for issuance, minting, burning, reserve accounting, and rewards for custom USDC-backed stablecoins. Implement onboarding, reporting, monitoring, and internal tooling, collaborate with cross-functional teams, and write well-tested production code across backend and on-chain surfaces.
Top Skills:
EthereumEvmGeminiGenerative Ai CopilotsGleanGoLibrechatSmart ContractsSolidityUsdc
Blockchain • eCommerce • Fintech • Payments • Software • Financial Services • Cryptocurrency
Own and build Block's furnisher and consumer reporting disputes program under FCRA end-to-end: policies, controls, monitoring, remediation workflows, investigations, training, and regulator engagement. Define reasonable investigation standards, design data-correction workflows with product and engineering, root-cause recurring defects, and advise teams to bake in reporting accuracy for Cash App Credit Score and related products.
eCommerce • Healthtech • Kids + Family • Retail • Social Media
Lead full-cycle recruiting for Babylist's most complex technical roles (senior to director-level engineers, principal PMs, AI/Builder profiles). Partner with engineering and product leaders, build hiring intelligence (trackers, dashboards, funnel analysis), drive offer strategy in hard negotiations, mentor recruiters, manage agency performance, and raise recruiting standards through calibration, coaching, and data-driven recommendations.
Top Skills:
AIChatgptClaude
What you need to know about the San Francisco Tech Scene
San Francisco and the surrounding Bay Area attracts more startup funding than any other region in the world. Home to Stanford University and UC Berkeley, leading VC firms and several of the world’s most valuable companies, the Bay Area is the place to go for anyone looking to make it big in the tech industry. That said, San Francisco has a lot to offer beyond technology thanks to a thriving art and music scene, excellent food and a short drive to several of the country’s most beautiful recreational areas.
Key Facts About San Francisco Tech
- Number of Tech Workers: 365,500; 13.9% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: Google, Apple, Salesforce, Meta
- Key Industries: Artificial intelligence, cloud computing, fintech, consumer technology, software
- Funding Landscape: $50.5 billion in venture capital funding in 2024 (Pitchbook)
- Notable Investors: Sequoia Capital, Andreessen Horowitz, Bessemer Venture Partners, Greylock Partners, Khosla Ventures, Kleiner Perkins
- Research Centers and Universities: Stanford University; University of California, Berkeley; University of San Francisco; Santa Clara University; Ames Research Center; Center for AI Safety; California Institute for Regenerative Medicine

.png)

