Top Chief of Staff Jobs in San Francisco, CA

The Chief of Staff supports Oncology and Hematology Therapeutic Area leaders by managing strategic priorities, operational planning, leadership meetings, communications, and cross-functional initiatives. The role tracks milestones, coordinates stakeholders, facilitates decision-making, monitors organizational health, supports change management, and leads project and Operations Partner communities. It requires extensive experience in pharmaceutical or other regulated industries, global matrix environments, complex program leadership, executive communication, and strategic project execution.

Work directly with both founders to execute strategic initiatives across go-to-market, product, recruiting, and operations. Build and scale outbound and GTM systems, translate founder and customer insights into action, lead cross-functional special projects, create repeatable processes, and use AI tools and automation to increase team leverage.

The Chief of Staff will work directly with founders to drive strategic and operational priorities across customer communications, contracts, compliance, sales, partnerships, market research, recruiting, finance, and company operations. Responsibilities include coordinating SOC 2 compliance, managing vendors and legal work, supporting business development, representing the company externally, identifying bottlenecks, and converting ambiguous priorities into organized projects with measurable progress.

Acts as the CEO’s right hand, translating company priorities into operating plans, tracking owners and deadlines, analyzing commercial and operational performance, and running leadership rhythms. Owns cross-functional project delivery, process redesign, decision tracking, and executive materials. The role requires strong program management, analytical and financial understanding, influence without authority, structured communication, and independent execution.

Serves as strategic partner and force multiplier to the Chief Revenue Officer, driving revenue leadership operations, strategic planning, goal tracking, executive and board communications, customer and partner engagement, and cross-functional resolution of business priorities. The role manages CRO office initiatives, optimizes executive time, builds scalable operating processes, and coordinates with senior leaders across Sales, Finance, Operations, People, and other teams.

The Chief of Staff serves as a strategic partner to the CEO and COO, managing executive operating cadence, board and investor relations, enterprise initiatives, OKRs, strategic planning, and organizational effectiveness. The role leads fundraising strategy across venture, philanthropic, and government sources, including pipeline management, grant execution, investor materials, and stakeholder engagement. It also coordinates executive meetings, tracks KPIs, supports decision-making, and manages cross-functional projects. Travel to markets, conferences, and company meetings is approximately 20–25%.

Partner with the CEO to drive execution across planning, hiring, product, GTM, finance, and culture. Own operating cadence, track leadership priorities, lead cross-functional initiatives, prepare high‑stakes CEO communications, support board/investor and people processes, and build scalable systems to keep the company aligned and accountable.

Chief of Staff to the CEO responsible for driving company priorities, building the organization’s operating cadence, managing KPI reporting, leading cross-functional special projects, and increasing executive leverage. The role requires turning ambiguous problems into measurable plans, coordinating leaders and external partners, deploying AI effectively across operations, and improving organizational efficiency in a high-growth B2B SaaS environment.

Serve as a strategic surrogate to the Chief Strategy Officer: represent the CSO in meetings, craft executive communications and presentations, drive cross-functional strategy initiatives, monitor progress and alignment, collaborate with engineering/product/sales, and articulate the Strategy org's impact internally and externally. Requires technical fluency, strong analytics, and executive presence to accelerate high-impact projects and customer engagements.

Leads commercial growth initiatives from concept through traction, including market sizing, business cases, go-to-market strategy, competitive intelligence, and cross-functional execution. Drives executive committee operating rhythms, board preparation, strategic initiative tracking, decision-making, and accountability across Product, Clinical, Marketing, Finance, Sales, and executive stakeholders.

Serve as a strategic partner to the Head of Engineering and leadership team during rapid organizational growth. Own operating rhythms, improve decision-making and execution, diagnose organizational friction, and create plans for cross-functional delivery. Translate technology strategy into priorities, operating plans, and measurable outcomes. Apply AI tools to streamline processes and reduce operational toil while influencing senior technical leaders and driving sustainable organizational practices.

Leads Waymark’s strategic planning, OKR management, executive operating rhythm, internal communications, and business process development. Partners with the CEO and executive team to translate strategy into goals, improve cross-functional coordination, manage decision-making systems, produce executive and board communications, and drive high-priority initiatives. The role requires strong analytical, communication, financial modeling, process design, and influence skills in a healthcare-focused, high-growth environment.

Support senior leaders by managing complex calendars, meetings, travel, communications, presentations, action items, and confidential information. Coordinate cross-functional priorities, prepare executives for meetings, track follow-ups, improve workflows, and support special projects in a fast-paced healthcare organization.

Serve as strategic partner to the SVP of Product to scale product leadership: run leadership rhythms, own headcount and budget planning, drive AI enablement, curate external product narrative, manage org-health metrics, and resolve cross-functional structural issues to increase decision speed and org effectiveness.

Serve as the CEO’s strategic operator and thought partner, managing executive-office operations, planning rhythms, OKRs, dashboards, board preparation, fundraising support, stakeholder relationships, and cross-functional initiatives. The role improves CEO leverage, drives accountability, synthesizes business performance, and ensures strategic priorities progress across Engineering, Go-to-Market, and Operations.

The Chief of Staff serves as the CEO’s strategic operator and thought partner, managing executive-office operations, planning rhythms, OKRs, dashboards, board preparation, fundraising support, stakeholder relationships, and cross-functional initiatives. The role drives accountability, synthesizes business performance, improves leadership meetings, handles confidential information, and represents the CEO with internal and external stakeholders. Success requires strong judgment, exceptional writing, AI fluency, and the ability to execute ambiguous, high-impact work under pressure.

Own the CEO’s calendar, follow-ups, project-management systems, hiring operations, content execution tracking, metrics, reporting, and special projects. The role protects executive focus, enforces accountability across teams, coordinates hiring pipelines, analyzes financial and performance data, and builds scalable operating rhythms. It is a high-trust Executive Operations position with a performance-based path toward Chief of Staff responsibilities.

Serve as Pepr AI’s first business hire, partnering with founders, customers, and engineers. Own customer engagements, performance reporting, proposals, and follow-through; translate customer needs into product requirements and shipped improvements; track KPIs, support planning, resolve execution blockers, and improve internal processes. Support founder-led sales through collateral, pipeline management, outbound experiments, and other go-to-market initiatives.

Serve as Chief of Staff to the CHRO, managing the People leadership operating cadence, leading cross-functional initiatives end-to-end, crafting executive communications, resolving issues proactively, and representing CHRO priorities across the organization.

The Chief of Staff partners with the CEO and executive team to translate company priorities into action. Responsibilities include leading cross-functional initiatives, preparing executive and board materials, managing operating rhythms and KPIs, conducting strategic research and analysis, resolving organizational bottlenecks, prioritizing resources, and ensuring initiatives reach measurable outcomes. The role requires high ownership, strong judgment, analytical ability, executive communication, and comfort working onsite in a fast-paced startup environment.

Serve as the Chief Growth Officer’s strategic operator, leading GTM execution across Sales, Marketing, Channel, Customer Success, Product, and Finance. Own revenue operations, pricing, deal governance, forecasting, territory and quota planning, data unification, HubSpot architecture, executive dashboards, pipeline optimization, and Q2C processes. Manage a HubSpot Administrator, improve commercial analytics, establish operating cadence, and deploy AI-enabled workflows across the GTM technology stack.

Serve as the CEO’s strategic thought partner and cross-functional operator. Lead ambiguous special projects, coordinate initiatives across engineering, go-to-market, finance, and people teams, maintain leadership operating cadence, improve internal processes, and prepare board and investor materials. The role also tracks priorities, ensures follow-through, supports executive decision-making, and helps scale the company’s operating systems.

Partners with the CEO and executive team to shape corporate strategy and operationalize priorities across the organization. Leads market and competitive analysis, annual strategy, KPI monitoring, executive meeting cadence, board and investor preparation, and cross-functional initiatives. Acts as connective tissue across Product, Sales, Engineering, Operations, Government Affairs, and Finance while managing ambiguous, sensitive projects and ensuring leadership alignment and follow-through.

The BizOps Lead will advise the CEO, manage strategic initiatives, coordinate programs, prepare communications for stakeholders, and lead special projects.

Chief of Staff supporting Global Security Customer Engineering leadership by managing executive cadences, strategic programs, communications, meeting briefings, recognition initiatives, change management, and stakeholder relationships. The role translates ambiguous priorities into executable workstreams, coordinates cross-functional teams, supports executive alignment, and serves as a leadership proxy across Google Cloud and Google.