Top Chief of Staff Jobs in San Francisco, CA

The Chief of Staff will support the President in driving strategic initiatives, cross-functional projects, and decision-making for Ambience Healthcare, focusing on critical problem-solving and collaboration with senior executives.

Operate as a founder-facing technical chief of staff owning GTM, operations, strategy, and special projects. Drive founder leverage, build zero-to-one go-to-market motions and pilots, establish company operating rhythms (planning, KPIs, communications), and resolve high-priority cross-functional problems end-to-end.

Partner directly with the CEO to scale the company by running high-leverage projects end-to-end, building structure, automating operations with AI, owning follow-through across hiring, fundraising, sales, product, engineering, marketing and ops, attending key meetings, picking up tasks as needed, and traveling to serve customers. Work is fully in-person in San Francisco and expands scope over time.

Partner with the CEO to create operational clarity and accountability across a fast-growing AI startup. Own vendor/contract management, finance/ops logistics, recruiting-process machinery, cross-team coordination, leadership operating rhythms, and high-priority special projects. Convert founder intuition into scalable processes while retaining agility.

As Executive Chief of Staff, you'll manage the CEO's priorities, facilitate communication, align cross-functional teams, and support strategic initiatives. The role emphasizes high-level organization, decision-making assistance, and effective stakeholder engagement.

The Chief of Staff at NomadicML will partner with founders to operationalize strategic plans, drive internal communication, lead projects, and support fundraising efforts, ensuring alignment across product, research, and growth initiatives.

Partner directly with the CEO to drive high-impact strategic and operational initiatives, lead cross-functional projects, build operating systems and planning frameworks, prepare executive and board materials, and leverage AI tools to automate workflows and accelerate decision-making across the company.

Partner with the CEO and cross-functional leaders to translate ambiguity into clear plans, manage executive operating rhythms, drive commercial deals, prepare executive and board materials, lead special cross-functional projects (including AI adoption), and improve operational effectiveness and communication.

Serve as strategic partner and operational proxy to the Chief People Officer, driving cross-functional alignment, leading high-impact people initiatives, managing global People & Places program timelines and budgets, simplifying processes, and optimizing resources to enable high-velocity execution and strong fiscal stewardship across the organization.

Run marketing org operations and planning cadence, translate VP priorities into executable plans, manage budget/headcount trade-offs, ensure cross-functional coordination, own leadership materials and special projects, and improve org cadence and accountability so programs ship on time and leaders focus on strategy.

The Chief of Staff will assist the CEO across sales, product, marketing, and operations, ensuring tasks are completed effectively and efficiently as the company scales.

Provide hands-on executive support to the Chief of Staff and CEO, manage executive calendars, travel, board and investor meeting logistics, and lead cross-functional strategic projects. Own executive communications, prepare briefing materials, track decisions and follow-up, and cover Executive Office operations during a three-month maternity leave. Support long-term strategic initiatives and may transition into Commercial, IR, or Finance roles.

Work directly with the founders as a generalist operator: own cross-functional, high-impact initiatives end-to-end, streamline operations across sales, CS, product, engineering, and hiring, handle admin/logistics, coordinate communications and follow-ups, and solve ambiguous urgent problems to free founder bandwidth.

The Chief of Staff will enhance customer experience, optimize operations, manage initiatives, and bridge product and service areas while working closely with the CEO and COO.

Partner with the VP of Operations and executive team to turn strategy into execution: run company planning (OKRs), operating cadence, KPIs, SOC 2 readiness, acquisition integration, investor/vendor relations, recruiting loops, and cross-functional initiatives while driving AI adoption and scaling processes.

Partner with the CEO to own company metrics, operating cadence, and strategic initiative portfolio. Run board/investor materials and key workstreams, remove CEO bottlenecks, coordinate cross-functional launches (multi-state, compliance, vendor migrations), and occasionally lead functions until they have permanent leaders.

Partner with the Chief Client Officer to drive strategic scaling initiatives, lead the PMO, act as cross-functional liaison, grow and manage the expert community, roll out AI automations, and deliver measurable impact across Customer Success, Operations, and Programming.

Partner with the CEO to drive strategy and execution, remove organizational bottlenecks, translate decisions into cross-functional action, and represent the CEO externally. Build domain knowledge of AI/ML, GPU finance, and datacenter deal dynamics while coordinating leadership alignment and ensuring measurable outcomes. Role requires daily in-person presence in San Francisco.

High-trust Chief of Staff to the CEO who translates strategy into measurable initiatives, drives cross-functional alignment, systems for finance/legal/compliance/hiring, supports GTM and partnerships, owns fundraising and investor materials, builds early-stage teams, and automates operational processes for hyper-growth.

In this role, you will drive strategic projects, build financial models, analyze data, design processes, and manage initiatives for the founding team, contributing to the operational efficiency and growth of the startup.

Work directly with the CEO on highest-priority company initiatives across go-to-market, pricing, partnerships, hiring, investor/board engagement, and strategy. Act as a trusted operator empowered to drive outcomes, represent the CEO, and move cross-functional work forward with urgency. Role is in-person in San Francisco, demanding, and intended as a multi-year growth opportunity into leadership.

The Chief of Staff will drive company execution, manage key initiatives, prepare executive materials, and lead critical projects as needed.

Partner with the COO and exec team to translate strategy into plans, run leadership and planning cadences, lead cross-functional projects, prepare board/investor materials, define and track OKRs, and build processes to close organizational gaps.

Partner with the CEO to drive high-priority, cross-functional initiatives, scale operating rhythms, run board and investor prep, resolve company bottlenecks, and translate board-level strategy into execution. Own ambiguous projects, improve decision clarity, and help tell the companys external narrative while preparing to run a P&L in the future.

Senior strategic partner to the CCMO who drives cross-functional delivery, runs leadership cadence and governance, translates strategy into priorities, manages confidential high‑impact projects, shapes executive engagements, and ensures accountability across Brand, Communications, Marketing and Operations.