Top Chief of Staff Jobs in San Francisco, CA

The Chief of Staff will oversee strategic business moves, finance management, vendor negotiations, and develop partnerships, acting as a close advisor to the CEO.

Partner with the CEO to coordinate executive priorities, prepare communications and fundraising/board materials, evaluate partnerships, and use AI to automate G&A workflows while synthesizing company performance across functions.

The Chief of Staff will support the President in driving strategic initiatives, cross-functional projects, and decision-making for Ambience Healthcare, focusing on critical problem-solving and collaboration with senior executives.

As Executive Chief of Staff, you'll manage the CEO's priorities, facilitate communication, align cross-functional teams, and support strategic initiatives. The role emphasizes high-level organization, decision-making assistance, and effective stakeholder engagement.

Partner directly with the CEO to drive high-impact strategic and operational initiatives, lead cross-functional projects, build operating systems and planning frameworks, prepare executive and board materials, and leverage AI tools to automate workflows and accelerate decision-making across the company.

Partner with the CEO to coordinate executive priorities, lead cross-functional projects, oversee administrative and IT functions, support board governance, manage Executive Assistants, and build systems and processes to improve operational effectiveness across multisite Bay Area programs.

Partner with the CEO and executive team to drive high-stakes decisions, run executive operating cadences, lead cross-functional high-priority projects, and create CEO leverage through time architecture, communications, and rigorous follow-through.

Serve as the CEO's strategic and operational right hand at an AI LegalTech startup: prepare executive/board/investor materials, build financial models and decks, contribute litigation expertise to product content, validate LLM-generated analyses, drive cross-functional execution, manage company operations (recruiting, vendor administration, OKRs), represent the CEO, and handle special projects across finance, legal, and partnerships.

The Chief of Staff at NomadicML will partner with founders to operationalize strategic plans, drive internal communication, lead projects, and support fundraising efforts, ensuring alignment across product, research, and growth initiatives.

Serve as liaison between senior leadership and staff to drive strategic initiatives, oversee daily operations, track project deliverables, develop action plans, manage communications, and organize business-critical meetings while improving operational efficiency.

The Chief of Staff will assist the CEO across sales, product, marketing, and operations, ensuring tasks are completed effectively and efficiently as the company scales.

The Chief of Staff will partner with the CEO on strategic and operational initiatives, translating complex problems into structured plans, and promoting alignment across the organization.

Act as a judgment layer for founders, handling communications, GTM/BD ops, executive assistance, content and video ops, knowledge-graph maintenance, and extending agent automation to reduce manual work. Operate in-person in San Francisco with founder-level intensity and a focus on systems, taste, and automation.

Work directly with the CEO to increase leverage by triaging decisions, owning board and fundraising materials, leading cross-functional strategic projects (pricing, GTM, ICP), running planning cycles, and owning org design and senior recruiting. Act as escalation filter, drive follow-through, and produce CEO-ready writing and recommendations.

Work directly with the founders as a generalist operator: own cross-functional, high-impact initiatives end-to-end, streamline operations across sales, CS, product, engineering, and hiring, handle admin/logistics, coordinate communications and follow-ups, and solve ambiguous urgent problems to free founder bandwidth.

As Chief of Staff, drive strategic focus and execution for the CMO, managing operations and facilitating decision-making across global teams, with a strong emphasis on alignment and communication.

The Chief of Staff will partner with the CEO to drive execution, strategic planning, and operational initiatives across the company, ensuring alignment and enhancing efficiency.

Partner with the VP of Operations and executive team to turn strategy into execution: run company planning (OKRs), operating cadence, KPIs, SOC 2 readiness, acquisition integration, investor/vendor relations, recruiting loops, and cross-functional initiatives while driving AI adoption and scaling processes.

The Chief of Staff will enhance customer experience, optimize operations, manage initiatives, and bridge product and service areas while working closely with the CEO and COO.

The Chief of Staff will drive company execution, manage key initiatives, prepare executive materials, and lead critical projects as needed.

In this role, you will drive strategic projects, build financial models, analyze data, design processes, and manage initiatives for the founding team, contributing to the operational efficiency and growth of the startup.

The Chief of Staff will facilitate strategy execution, improve operational frameworks, and enhance cross-functional alignment within the Data organization at Coursera.

The Chief of Staff drives strategic planning, operational execution, and cross-functional alignment while supporting senior leadership in delivering key initiatives and stakeholder engagement.

Work directly with the CEO on highest-priority company initiatives across go-to-market, pricing, partnerships, hiring, investor/board engagement, and strategy. Act as a trusted operator empowered to drive outcomes, represent the CEO, and move cross-functional work forward with urgency. Role is in-person in San Francisco, demanding, and intended as a multi-year growth opportunity into leadership.

Serve as the executive owner for AI transformation at mid-market clients: convene and facilitate C-suite AI steering committees, build board-ready AI roadmaps tied to KPIs and ROI, coordinate delivery teams, unblock workstreams, surface expansion opportunities, and refine the AI Chief of Staff playbook to scale Pragmatico’s offerings.