Top Chief of Staff Jobs in San Francisco, CA

Chief of Staff partnering with the CEO and CCO to drive high-priority commercial initiatives and accelerate U.S. growth. Responsibilities include market strategy, enterprise sales, strategic accounts, partnerships, pricing, product marketing, customer expansion, founder leverage, cross-functional problem solving, and building commercial operating cadences, metrics, feedback loops, and repeatable processes.

Own business operations coordination across finance, people operations, administration, vendors, and AI-enabled workflows. Manage inbound triage, pipeline hygiene, customer follow-through, investor updates, PR and event logistics, and customer-facing sales collateral. Coordinate fractional teams and hold senior leaders accountable without direct authority. The role is full-time and in-person in San Francisco, supporting an early-stage plant intelligence startup.

Work directly with the CEO to drive ambiguous, high-priority initiatives to completion across operations, customer relationships, recruiting, finance, legal, strategy, vendors, and special projects. The role will establish lightweight systems, resolve bottlenecks, coordinate stakeholders, support hiring and customer engagement, translate technical context, and ensure critical company priorities do not fall through the cracks.

Serves as strategic partner to the President of Seramount, leading executive preparation, strategic prioritization, cross-functional initiatives, leadership operating rhythms, decision support, communications, organizational change, AI adoption, and employee engagement. The role translates strategy into coordinated execution, facilitates leadership decisions, and ensures commitments are completed across the organization.

The Chief of Staff will support the executive team by managing schedules, facilitating communication, and overseeing internal operations to enhance productivity.

Serves as a strategic partner to founders and executives by managing priorities, filtering decisions, translating vision into organizational action, preparing high-stakes meetings, synthesizing business reporting, coordinating stakeholders, identifying risks, supporting planning and resource allocation, drafting executive communications, managing confidential information, and leading special projects. The role also owns client satisfaction and evaluates whether engagements continue to meet evolving executive needs.

The Chief of Staff will work closely with the CEO in key business functions such as strategy, recruiting, and operations. The role requires exceptional interpersonal skills, strategic thinking, and a passion for health. Responsibilities include recruiting, investor relations, internal communications, brand management, and special projects, adapting to the needs of the company.

Drives major priorities and cross-functional projects across ActAI’s businesses from decision through execution. Identifies and solves business problems, tracks performance and ownership, leads expansion and organizational initiatives, analyzes markets and financials, and coordinates across product, technology, finance, people, and operations.

The Chief of Staff will support the Managing Director of AI, driving AI transformation, designing automated systems, managing client engagements, and ensuring effective delivery and operational strategies within the organization.

The Chief of Staff will support the COO by managing operations, driving performance culture through data, and overseeing partnerships. Responsibilities include leading operational rollouts and defining KPIs.

The Chief of Staff will assist the CEO across product, marketing, and operations by handling various responsibilities as needed, including customer support and data analysis.

Work directly with the CEO to execute strategic initiatives across go-to-market, fundraising, hiring, expansion, and customer success. Build scalable operating systems, processes, automations, and company rhythms; coordinate priorities, owners, deadlines, and outcomes; incubate high-priority initiatives; and prepare board materials, investor updates, decision memos, and company communications.

Serve as the CEO’s closest partner and first Business Operations hire. Own enterprise contracts, reporting infrastructure, revenue operations, pricing analysis, board materials, investor updates, operating cadence, partner relationships, and high-priority special projects. Build processes from scratch, solve ambiguous problems, drive commercial outcomes, and provide analysis that supports company and board decisions.

The Chief of Staff role involves managing operational tasks such as HR, finance ops, vendor management, and logistics. This position ensures efficient processes and supports the CEO across various functions in the company.

Serve as a strategic advisor and operational partner to the CEO, driving executive operating cadence, cross-functional strategy execution, transformation initiatives, and executive communications. Lead enterprise initiatives, develop executive materials and dashboards, remove execution barriers, and implement AI-enabled workflows to increase CEO leverage and organizational alignment.

The Chief of Staff/Strategic Finance role involves financial modeling, identifying bottlenecks in business pipelines, and managing strategic initiatives across the company. Responsibilities include goal setting, running reviews, and managing board meetings.

Serve as the COO's trusted partner to translate strategy into executable plans, lead end-to-end cross-functional initiatives, run analyses and decision memos, manage operating cadences, prepare executive materials, and drive outcomes without direct authority.

Support the CEO as an external force multiplier: run capital formation processes, craft investor/partner decks and memos, drive strategic partnerships with frontier labs and enterprises, build executive relationship systems, and lead high-impact confidential projects requiring judgment, discretion, and flawless execution.

The Chief of Staff will partner with the co-founder and leadership team to scale internal operations across a rapidly growing philanthropic organization. Responsibilities include running OKRs, KPI dashboards, operating rhythms, leadership meetings, decision-making processes, internal systems, AI-enabled tooling, communication norms, knowledge management, strategic initiatives, and occasional partner support. The role requires proactive problem-solving, strong execution, clear communication, comfort with ambiguity, and approximately seven or more years of relevant experience.

Work directly with founders to drive multi-GW energy projects end-to-end: deliver construction and procurement milestones, lead special projects, support large-scale project and equity financing, hire across levels, and resolve urgent operational issues on-site.

Serve as the right hand to the Head of Sales, running sales cadence, driving pipeline visibility and forecasting, enabling reps with materials, coordinating cross-functional GTM work, structuring strategic problems, supporting hiring/onboarding, and preparing executive-level communications to improve sales execution and accountability.

Own end-to-end outcomes for GTM, partnerships, and operations. Provide high-level strategic thinking with a bias for action, operate under ambiguous KPIs, and scale the function by hiring and extending teams as needed.

The Chief of Staff/Business Operations Manager will drive strategic initiatives, optimize processes, and collaborate with executives to achieve company objectives.

The Chief of Staff will support the CEO by prioritizing company initiatives, driving cross-functional projects, and ensuring leadership alignment in a fast-paced environment.

The Chief of Staff will assist the CEO in strategic priorities, drive sales and product operations, manage investor relations, and oversee internal initiatives, ensuring organizational excellence and scaling efforts.